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天然产物生物合成潜力反映了广泛分布的细菌分类群内的宏观进化多样化。

Natural product biosynthetic potential reflects macroevolutionary diversification within a widely distributed bacterial taxon.

机构信息

Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal.

iBB-Institute for Bioengineering and Biosciences and i4HB-Institute for Health and Bioeconomy, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal.

出版信息

mSystems. 2023 Dec 21;8(6):e0064323. doi: 10.1128/msystems.00643-23. Epub 2023 Nov 29.

DOI:10.1128/msystems.00643-23
PMID:38018967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10734526/
Abstract

This is the most comprehensive study performed thus far on the biosynthetic potential within the family. Our findings reveal intertwined taxonomic and natural product biosynthesis diversification within the family. We posit that the carbohydrate, peptide, and secondary metabolism triad synergistically shaped the evolution of this keystone bacterial taxon, acting as major forces underpinning the broad host range and opportunistic-to-pathogenic behavior encompassed by species in the family. This study further breaks new ground for future research on select spp. as reservoirs of novel drug leads.

摘要

这是迄今为止针对 科内生物合成潜力进行的最全面研究。我们的研究结果揭示了该科内分类群和天然产物生物合成多样化的交织关系。我们假设碳水化合物、肽和次生代谢三联体协同塑造了这个关键细菌分类群的进化，是支撑科内物种广泛宿主范围和机会性病原体行为的主要力量。这项研究为进一步研究特定的 spp.作为新型药物先导物的储库奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2a6/10734526/87e9c949e513/msystems.00643-23.f007.jpg
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