Natural product biosynthetic potential reflects macroevolutionary diversification within a widely distributed bacterial taxon.

This is the most comprehensive study performed thus far on the biosynthetic potential within the family. Our findings reveal intertwined taxonomic and natural product biosynthesis diversification within the family. We posit that the carbohydrate, peptide, and secondary metabolism triad synergistically shaped the evolution of this keystone bacterial taxon, acting as major forces underpinning the broad host range and opportunistic-to-pathogenic behavior encompassed by species in the family. This study further breaks new ground for future research on select spp. as reservoirs of novel drug leads.