Efficacy of the combination of amphotericin B and echinocandins against and in the host model.

Multidrug resistance is a rising problem among non- species, such as . This therapeutic problem has been very important during the COVID-19 pandemic. The World Health Organization has included in its global priority list of health-threatening fungi, to study this emerging multidrug-resistant species and to develop effective alternative therapies. In the present study, the synergistic effect of the combination of amphotericin B and echinocandins has been demonstrated against blood isolates of . Different susceptibility responses were also observed between aggregative and non-aggregative phenotypes. The antifungal activity of these drug combinations against was also demonstrated in the host model of candidiasis, confirming the suitability and usefulness of this model in the search for solutions to antimicrobial resistance.