Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Pharmacogenomics. 2023 Dec;24(18):931-942. doi: 10.2217/pgs-2023-0168. Epub 2023 Nov 29.
To evaluate the association between gene polymorphisms and susceptibility of antituberculosis drug-induced hepatotoxicity (ATDH). We searched the PubMed, Cochrane Library, Embase, Web of Science, Wan Fang and China National Knowledge Infrastructure database from inception to 2022. Nine case-control studies with 1129 cases and 2203 controls were included. Among four SNPs reported in two or more studies, the final results indicated that SNP rs4149014 was significantly associated with decreased ATDH risk (dominant model, odds ratio: 0.73; 95% CI: 0.55-0.97; p = 0.03; allele model, odds ratio: 0.69; 95% CI: 0.55-0.86; p = 0.001), and the trial sequential analysis also confirmed this significant association. gene SNP rs4149014 was significantly associated with lower risk of ATDH susceptibility.
评价基因多态性与抗结核药物性肝损伤（ATDH）易感性的相关性。
检索 PubMed、Cochrane Library、Embase、Web of Science、万方和中国知网数据库，检索时间从建库至 2022 年。纳入符合标准的病例对照研究 9 项，共计 1129 例病例和 2203 例对照。对报道超过 2 项研究的 4 个 SNP 进行分析，最终结果显示 SNP rs4149014 与 ATDH 风险降低显著相关（显性模型，比值比：0.73；95%置信区间：0.55-0.97；p=0.03；等位基因模型，比值比：0.69；95%置信区间：0.55-0.86；p=0.001），且试验序贯分析也证实了这种显著相关性。
基因 SNP rs4149014 与较低的 ATDH 易感性风险显著相关。
