Rapid and General Access to α-Haloketones Using Quaternary Ammonium Salts as Halogen Sources.
作者信息
Wu Nan, Jiang Mengfei, Cao Ashley, Huang Lei, Bo Xiumei, Xu Zhou
机构信息
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
出版信息
J Org Chem. 2023 Dec 15;88(24):17368-17380. doi: 10.1021/acs.joc.3c02195. Epub 2023 Nov 29.
PMID:38019647
Abstract
A general, rapid, and scalable method for the preparation of α-halogenated ketones using N-alkenoxypyridinium salts as substrates and quaternary ammonium salts as halogen sources was developed, featuring mild reaction conditions, excellent functional group tolerance, short reaction times, and a wide substrate scope.
摘要
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