Dogan Zeki, Guven Emine Seda Guvendag, Albayrak Mehmet, Guven Suleyman
Departments of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
J Med Ultrasound. 2022 Nov 9;31(3):201-205. doi: 10.4103/jmu.jmu_34_22. eCollection 2023 Jul-Sep.
Intrauterine growth restriction (IUGR) refers to fetuses that are small for their gestational age. There is no effective test to predict this disease. The aim of our study is whether fetal three-dimensional (3D) ultrasonography (USG)-assisted thymus volume (TV) measurement predicts IUGR cases.
Fetal 3D USG thymus measurement between 15 and 24 weeks of gestation was performed in a total of 100 women of reproductive age. Fetal TV was measured using the virtual organ computer-assisted analysis system program. All cases were followed up in terms of pregnancy complications until delivery.
IUGR was developed in six cases in total. In cases with IUGR, mean fetal TV was found to be statistically significantly lower than in healthy cases without it. When the fetal TV was taken as 0.1645, the sensitivity was calculated as 89.5% and the specificity as 50% for predicting IUGR. The use of low fetal volume parameters is a significant and good indicator for predicting IUGR according to the binary logistic regression analysis result.
According to the results of this study, 3D fetal TV measurement may be used in routine second-trimester sonographic anomaly screening to predict the development of fetal IUGR. In this way, fetal mortality and morbidity caused by IUGR may be reduced.
宫内生长受限（IUGR）是指胎儿小于其孕周。目前尚无有效的检测方法来预测这种疾病。我们研究的目的是探讨胎儿三维（3D）超声（USG）辅助测量胸腺体积（TV）能否预测IUGR病例。
对100名育龄妇女在妊娠15至24周期间进行胎儿3D USG胸腺测量。使用虚拟器官计算机辅助分析系统程序测量胎儿TV。所有病例均随访至分娩，观察妊娠并发症情况。
总共6例发生IUGR。发现IUGR病例的平均胎儿TV在统计学上显著低于无IUGR的健康病例。当将胎儿TV设定为0.1645时，预测IUGR的敏感性计算为89.5%，特异性为50%。根据二元逻辑回归分析结果，胎儿体积参数较低是预测IUGR的一个显著且良好的指标。
根据本研究结果，3D胎儿TV测量可用于常规孕中期超声异常筛查，以预测胎儿IUGR的发生。这样可降低IUGR所致的胎儿死亡率和发病率。
