Department of Emergency, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310052, China.
Zhejiang Provincial Critical Research Center for Emergency Medicine Clinic, Hangzhou 310052, China.
J Diabetes Res. 2023 Nov 9;2023:4388437. doi: 10.1155/2023/4388437. eCollection 2023.
This review summarizes the correlation between diabetes mellitus (DM) and gastric cancer (GC) from the perspectives of epidemiology, drug use, and potential mechanisms. The association between DM and GC is inconclusive, and the positive direction of the association reported in most published meta-analyses suggests that DM may be an independent risk factor for GC. Many clinical investigations have shown that people with DM and GC who undergo gastrectomy may have better glycemic control. The potential link between DM and GC may involve the interaction of multiple common risk factors, such as obesity, hyperglycemia and hyperinsulinemia, infection, and the use of metformin. Although and data support that infection status and metformin can influence GC risk in DM patients, there are conflicting results. Patient survival outcomes are influenced by multiple factors, so further research is needed to identify the patients who may benefit.
这篇综述从流行病学、药物使用和潜在机制的角度总结了糖尿病（DM）与胃癌（GC）之间的相关性。DM 与 GC 之间的关联尚无定论，大多数已发表的荟萃分析报告的关联呈阳性方向，表明 DM 可能是 GC 的一个独立危险因素。许多临床研究表明，接受胃切除术的 DM 和 GC 患者可能具有更好的血糖控制。DM 和 GC 之间的潜在联系可能涉及多种常见危险因素的相互作用，如肥胖、高血糖和高胰岛素血症、感染和二甲双胍的使用。尽管 和 数据支持 感染状况和二甲双胍可以影响 DM 患者的 GC 风险，但结果存在冲突。患者的生存结果受多种因素的影响，因此需要进一步研究以确定可能受益的患者。
