State Key Laboratory of Food Nutrition and Safety, Food Biotechnology Engineering Research Center of Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, China.
Wecare Probiotics Co., Ltd., Suzhou, Jiangsu 215200, China.
Food Funct. 2022 Oct 3;13(19):9947-9958. doi: 10.1039/d2fo01109c.
BL21 (BL21) possesses hypoglycemic activity, but its anti-diabetic mechanism has rarely been illustrated. In the present work, the effects of BL21 on type 2 diabetes mellitus (T2DM) were investigated in diabetic mice induced a high-fat diet combined with streptozotocin (STZ). Our data indicated that BL21 at a dose of 10 CFU per day significantly lowered the levels of fasting blood glucose and alleviated insulin resistance in diabetic mice. Meanwhile, BL21 enhanced the anti-oxidative capacity, increased the hepatic glycogen content, and significantly decreased the gene expression levels of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) in the livers of diabetic mice. Endotoxemia-related inflammation and impaired intestinal barrier function in diabetic mice were also improved using BL21. More importantly, the disturbance of intestinal flora was regulated by BL21, including increased levels of the genera , , and and decreased levels of , , and . Collectively, the amelioration of T2DM BL21 supplementation might be partially attributed to regulation of the parameters related to glucose metabolism and the modulation of gut microbiota. Therefore, BL21 could be a potential functional food for ameliorating T2DM.
BL21（BL21）具有降血糖活性，但很少有研究表明其抗糖尿病机制。在本工作中，研究了 BL21 对高脂饮食联合链脲佐菌素（STZ）诱导的 2 型糖尿病（T2DM）小鼠的作用。我们的数据表明，BL21 每天 10 CFU 的剂量可显著降低糖尿病小鼠的空腹血糖水平并缓解胰岛素抵抗。同时，BL21 增强了抗氧化能力，增加了肝糖原含量，并显著降低了糖尿病小鼠肝脏中葡萄糖-6-磷酸酶（G6Pase）和磷酸烯醇丙酮酸羧激酶（PEPCK）的基因表达水平。BL21 还改善了糖尿病小鼠的内毒素血症相关炎症和受损的肠道屏障功能。更重要的是，BL21 调节了肠道菌群的紊乱，包括增加了属 、 、 和 的水平，降低了属 、 、 和 的水平。总之，BL21 改善 T2DM 可能部分归因于调节与葡萄糖代谢相关的参数和调节肠道微生物群。因此，BL21 可以作为改善 T2DM 的潜在功能性食品。
