Wile A G, Kar R, Cohen R A, Jakowatz J G, Opfell R W
Cancer. 1987 Feb 15;59(4):695-700. doi: 10.1002/1097-0142(19870215)59:4<695::aid-cncr2820590406>3.0.co;2-g.
Cisplatin (DDP) is attractive for use in regional chemotherapy because of its tendency for protein binding. A study of regional chemotherapy was conducted in rabbits bearing the VX-2 carcinoma. Modes of therapy examined were intravenous (IV), intra-arterial (IA), IA with stopflow, IA with outflow occlusion, and isolation-perfusion (I-P). Each mode was evaluated by examining the pharmacokinetics of DDP in systemic and regional administration and measuring tissue concentrations of DDP. It was observed that the systemic exposure to DDP was significantly less for IA with outflow occlusion and I-P when compared to IV, IA, or IA with stopflow occlusion (P = 0.003). Tumor concentrations were highest with IA infusion with outflow occlusion (P = 0.002) and IA stopflow occlusion (P = 0.03). Tumor tissue concentrations were always higher than adjacent muscle DDP concentrations. The authors conclude that significant pharmacologic advantage can be demonstrated for certain modes of DDP administration in this rabbit model, and that these promising results should be followed by clinical trials.
顺铂（DDP）因其与蛋白质结合的倾向而在区域化疗中具有应用价值。对携带VX - 2癌的兔子进行了区域化疗研究。所研究的治疗方式包括静脉注射（IV）、动脉内注射（IA）、动脉内注射并阻断血流、动脉内注射并阻断流出以及隔离灌注（I - P）。通过检查顺铂在全身和区域给药时的药代动力学以及测量顺铂的组织浓度来评估每种治疗方式。结果发现，与静脉注射、动脉内注射或动脉内注射并阻断血流相比，动脉内注射并阻断流出以及隔离灌注时顺铂的全身暴露量显著更低（P = 0.003）。动脉内注射并阻断流出时肿瘤浓度最高（P = 0.002），动脉内注射并阻断血流时肿瘤浓度也较高（P = 0.03）。肿瘤组织浓度始终高于相邻肌肉的顺铂浓度。作者得出结论，在该兔子模型中，某些顺铂给药方式可显示出显著的药理学优势，这些有前景的结果应继以临床试验。
