新型吡唑并噻吩并吡啶酮类化合物作为潜在的γ-氨基丁酸（GABA）受体调节剂
Novel pyrazolothienopyridinones as potential GABA receptor modulators.
作者信息
Vega Alanis Blanca Angelica, Wimmer Laurin, Ernst Margot, Schnürch Michael, Mihovilovic Marko D
机构信息
Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060 Vienna, Austria.
Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria.
出版信息
Monatsh Chem. 2023;154(12):1427-1439. doi: 10.1007/s00706-023-03063-6. Epub 2023 Apr 13.
UNLABELLED
The synthesis of novel pyrazolothienopyridinone derivatives as potential GABA receptor modulators was performed and is herein described. A crucial step of the synthesis involving handling unstable aminothiophenes was managed via two different synthetic strategies delivering a set of 8 target compounds.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s00706-023-03063-6.
未标注
进行了新型吡唑并噻吩并吡啶酮衍生物作为潜在γ-氨基丁酸（GABA）受体调节剂的合成，并在此进行描述。合成过程中涉及处理不稳定氨基噻吩的关键步骤通过两种不同的合成策略得以实现，得到了一组8种目标化合物。
补充信息
在线版本包含可在10.1007/s00706-023-03063-6获取的补充材料。
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