来自NuAge研究的认知健康的老年人中循环心血管疾病危险因素与认知表现之间的关联。

Associations between circulating cardiovascular disease risk factors and cognitive performance in cognitively healthy older adults from the NuAge study.

作者信息

Koblinsky Noah D, Carmichael Pierre-Hugues, Belleville Sylvie, Fiocco Alexandra J, Gaudreau Pierrette, Greenwood Carol E, Kergoat Marie-Jeanne, Morais José A, Presse Nancy, Laurin Danielle, Ferland Guylaine

机构信息

Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.

Center d'excellence sur le Vieillissement de Québec, Center de Recherche du Center Hospitalier Universitaire (CHU) de Québec-Université Laval and VITAM-Center de Recherche en Santé Durable, Center Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) de la Capitale Nationale, Québec, QC, Canada.

出版信息

Front Aging Neurosci. 2023 Nov 10;15:1274794. doi: 10.3389/fnagi.2023.1274794. eCollection 2023.

DOI:10.3389/fnagi.2023.1274794

PMID:38020779

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10668121/

Abstract

INTRODUCTION

Cardiovascular disease risk factors (CVRFs) contribute to the development of cognitive impairment and dementia.

METHODS

This study examined the associations between circulating CVRF biomarkers and cognition in 386 cognitively healthy older adults (mean age = 78 ± 4 years, 53% females) selected from the Quebec Longitudinal Study on Nutrition and Successful Aging (NuAge). Memory, executive function, and processing speed were assessed at baseline and 2-year follow-up. CVRF biomarkers included total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides, glucose, insulin, high sensitivity C-reactive protein (hs-CRP), homocysteine, protein carbonyls, and cortisol. Linear mixed models were used to determine associations between individual CVRF biomarkers and cognition at both time points.

RESULTS

HDL-C was most consistently associated with cognition with higher values related to better performance across several domains. Overall, stronger and more consistent relationships between CVRF biomarkers and cognition were observed in females relative to males.

DISCUSSION

Findings suggest that increases in the majority of circulating CVRFs are not associated with worse cognition in cognitively healthy older adults.

摘要

引言

心血管疾病风险因素（CVRF）会导致认知障碍和痴呆症的发展。

方法

本研究调查了从魁北克营养与成功老龄化纵向研究（NuAge）中选取的386名认知健康的老年人（平均年龄 = 78 ± 4岁，53%为女性）循环CVRF生物标志物与认知之间的关联。在基线和2年随访时评估记忆、执行功能和处理速度。CVRF生物标志物包括总胆固醇、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯、葡萄糖、胰岛素、高敏C反应蛋白（hs-CRP）、同型半胱氨酸、蛋白质羰基和皮质醇。使用线性混合模型确定两个时间点上个体CVRF生物标志物与认知之间的关联。