Aleid Abdulsalam, Alturaifi Manal Y, Alharbi Ruba I, Saleh Fatema, Alomari Lubna H, Hazazi Raghad, Sindi Hala A, Ahmed Rufaida A, Al Mutair Abbas
Neurosurgery, King Faisal University, Al-Ahsa, SAU.
College of Medicine, King Faisal University, Al-Ahsa, SAU.
Cureus. 2023 Oct 9;15(10):e46706. doi: 10.7759/cureus.46706. eCollection 2023 Oct.
The global surge in high body mass index (BMI) and obesity has led to various health complications. While numerous studies have shown that obesity disrupts female fertility, the specific effects of obesity on the success rate of assisted reproductive technology (ART) treatments in Saudi women have been less explored. This study aimed to delve into this gap, especially focusing on the correlation between BMI, ovarian reserve parameters, and ART outcomes among Saudi women.
A cross-sectional study was carried out from January to August 2023, concentrating on Saudi women aged 18 and above who underwent ART treatments for infertility. A total of 1071 women participated, with 155 completing an online survey and 916 responding through a hard copy from several Saudi hospitals. The data encompassed demographics, medical history, anthropometric details, ovarian reserve parameters, and ART results. For the analysis, Statistical Package for the Social Sciences (IBM SPSS Statistics for Windows, IBM Corp., Version 28.0, Armonk, NY) was utilized, applying descriptive statistics, the Chi-square test, and a linear regression model to discern connections between BMI, participant characteristics, and ART outcomes. A p-value of less than 0.05 was considered statistically significant.
Most participants were aged 25-34 (406) years and held a bachelor's degree (707). Over half (560) received fertility treatments in the past, with 37.9% (406) having polycystic ovary syndrome (PCOS) and 23.5% (252) with other fertility-impacting medical conditions. Interestingly, 62.1% (665) had not undergone any ART cycles. Of those who did, 51.6% (553) had clinical pregnancies leading to live births. About 23.8% (308) of those with clinical pregnancies faced miscarriages without successful live births. Furthermore, 17.6% (189) reported complications or side effects from past ART procedures, and 31.4% (336) were on ART-related medications or supplements. The linear regression highlighted that individuals with normal weight tended to undergo more ART cycles. However, those with a higher BMI exhibited increased chances of achieving clinical pregnancies and live births.
The study underscores the crucial relationship between BMI and ART efficacy in Saudi women. The data reveals that BMI can significantly influence ART treatment outcomes, especially concerning the number of cycles, clinical pregnancies, and live births. Consequently, BMI should be an essential consideration when evaluating and optimizing the success rates of ART procedures.
全球高体重指数（BMI）和肥胖率的激增导致了各种健康并发症。虽然众多研究表明肥胖会扰乱女性生育能力，但肥胖对沙特女性辅助生殖技术（ART）治疗成功率的具体影响尚未得到充分探索。本研究旨在深入探讨这一差距，特别关注沙特女性的BMI、卵巢储备参数与ART结局之间的相关性。
于2023年1月至8月开展了一项横断面研究，聚焦于年龄在18岁及以上、因不孕接受ART治疗的沙特女性。共有1071名女性参与，其中155名完成了在线调查，916名通过沙特几家医院的纸质问卷进行了回复。数据涵盖人口统计学、病史、人体测量细节、卵巢储备参数和ART结果。分析时，使用了社会科学统计软件包（IBM SPSS Statistics for Windows，IBM公司，版本28.0，纽约州阿蒙克），应用描述性统计、卡方检验和线性回归模型来识别BMI、参与者特征与ART结局之间的联系。p值小于0.05被认为具有统计学意义。
大多数参与者年龄在25 - 34岁（406人），拥有本科学历（707人）。超过一半（560人）曾接受过生育治疗，37.9%（406人）患有多囊卵巢综合征（PCOS），23.5%（252人）患有其他影响生育的疾病。有趣的是，62.1%（665人）未进行过任何ART周期。在进行过ART周期的人中，51.6%（553人）有临床妊娠并活产。临床妊娠者中约23.8%（308人）面临流产，未能成功活产。此外，17.6%（189人）报告过去的ART程序有并发症或副作用，31.4%（336人）正在服用ART相关药物或补充剂。线性回归表明，体重正常的个体往往接受更多的ART周期。然而，BMI较高的个体临床妊娠和活产的几率增加。
该研究强调了沙特女性BMI与ART疗效之间的关键关系。数据表明，BMI可显著影响ART治疗结局，尤其是在周期数、临床妊娠和活产方面。因此，在评估和优化ART程序成功率时，BMI应是一个重要的考虑因素。
