[百日咳二次复种疫苗的反应原性及流行病学效果研究结果]

[Results of a study of the reactogenicity and epidemiological effectiveness of a 2d revaccination against whooping cough].

作者信息

Baeva E A, Burgasov Iu A, Kolontarova I I, Glinskaia E V, Auzinia A V

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1979 Jun(6):15-8.

Abstract

The reactogenicity and epidemiological effectiveness of the second revaccination against pertussis were studied in conformity with all the conditions of a controlled epidemiological trial. The character of the distribution of local and fever reactions in children aged 6 years after the second revaccination with adsorbed DTP vaccine suggests the presence of high sensitivity to the pertussis component of absorbed DTP vaccine in children of this age group. The results obtained from the study of epidemiological effectiveness (in 15,621 children) indicated that the second revaccination of children aged 6 years (at an interval of 3 or more years after the first revaccination) was not advisable as it did not influence noticeably the pertussis incidence.

摘要

按照对照流行病学试验的所有条件，对百日咳第二次再接种的反应原性和流行病学效果进行了研究。用吸附百白破疫苗进行第二次再接种后，6岁儿童局部和发热反应的分布特征表明，该年龄组儿童对吸附百白破疫苗中的百日咳成分高度敏感。对流行病学效果的研究（涉及15621名儿童）结果表明，对6岁儿童（在第一次接种后间隔3年或更长时间）进行第二次再接种不可取，因为这对百日咳发病率没有明显影响。