Sokhin A A, Kovalenko A I, Kucheriavenko V S, Logvinova V M, Komarevskaia R V
Zh Mikrobiol Epidemiol Immunobiol. 1979 Jun(6):9-15.
The authors studied the reactigenic properties, immunological and epidemiological efficacy of vaccination of children aged under one year by the experimental schemes (AKDC-AKDC-K -- 1 ml, and AKDC-AKDC-K -- 0.5 ml) in comparison with the official pertussis, diphtheria, and tetanus immunization scheme. There proved to be a greater immunogenicity and a better protective effect against pertussis in vaccination according to the experimental schemes. The vaccine reactions were somewhat more incident in children vaccinated according to the AKDC-AKDC-K -- 1 ml scheme, but their essential reduction was reached with reduction of the pertussis antigen third vaccination dose to 0.5 ml.
作者研究了采用实验方案（AKDC - AKDC - K，1毫升，以及AKDC - AKDC - K，0.5毫升）对一岁以下儿童进行疫苗接种的反应原性、免疫学和流行病学效果，并与官方的百日咳、白喉和破伤风免疫方案进行了比较。结果证明，根据实验方案进行疫苗接种时，具有更高的免疫原性和对百日咳更好的保护作用。按照AKDC - AKDC - K，1毫升方案接种疫苗的儿童中，疫苗反应的发生率略高一些，但将百日咳抗原第三次接种剂量减至0.5毫升后，疫苗反应显著减少。
