Mousavere Ioanna, Kalampokis Georgios, Fousekis Fotios, Karayiannis Peter, Baltayiannis Gerasimos, Christodoulou Dimitrios
Department of Gastroenterology, University Hospital of Ioannina, Greece (Ioanna Mousavere, Fotios Fousekis, Gerasimos Baltayiannis, Dimitrios Christodoulou).
Department of Internal Medicine, University Hospital of Ioannina, Greece (Georgios Kalampokis, Gerasimos Baltayiannis, Dimitrios Christodoulou).
Ann Gastroenterol. 2023 Nov-Dec;36(6):589-598. doi: 10.20524/aog.2023.0834. Epub 2023 Oct 30.
Primary sclerosing cholangitis (PSC) is a chronic hepatic dysfunction characterized by inflammatory and tissue-degenerative strictures of the biliary tree, leading to cirrhosis and cholangiocarcinoma. The pathophysiological mechanisms involve immune-mediated responses. Numerous treatment modalities targeting the inflammatory aspects have been suggested, but a consensus on the best treatment option is lacking. This study aims to review the most up-to-date treatment options for PSC.
原发性硬化性胆管炎（PSC）是一种慢性肝功能障碍，其特征为胆管树的炎症性和组织退行性狭窄，可导致肝硬化和胆管癌。病理生理机制涉及免疫介导的反应。已经提出了许多针对炎症方面的治疗方法，但对于最佳治疗方案尚未达成共识。本研究旨在综述PSC的最新治疗方案。
