Department of Medical Microbiology and Biotechnology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
School of Medicine, Qazvin University of Medical Science, Qazvin, Iran.
Life Sci. 2024 Jan 1;336:122316. doi: 10.1016/j.lfs.2023.122316. Epub 2023 Nov 28.
Helicobacter pylori infection is a risk factor for the development of gastric cancer (GC), and the role of co-infection with viruses, such as Epstein-Barr virus, in carcinogenesis cannot be ignored. Furthermore, it is now known that genetic factors such as long non-coding RNAs (lncRNAs) are involved in many diseases, including GC. On the other side, they can also be used as therapeutic goals. Modified lncRNAs can cause aberrant expression of genes encoding proximal proteins, which are essential for the development of carcinoma. In this review, we present the most recent studies on lncRNAs in GC, concentrating on their roles in H. pylori and EBV infections, and discuss some of the molecular mechanisms of these GC-related pathogens. There was also a discussion of the research gaps and future perspectives.
幽门螺杆菌感染是胃癌（GC）发展的一个危险因素，病毒（如 EBV）的合并感染在致癌作用中不容忽视。此外，现在已知遗传因素，如长链非编码 RNA（lncRNA），参与许多疾病，包括 GC。另一方面，它们也可以用作治疗目标。修饰的 lncRNA 可以导致编码近端蛋白的基因异常表达，这对癌的发展是必需的。在这篇综述中，我们介绍了 lncRNA 在 GC 中的最新研究，重点讨论了它们在 H. pylori 和 EBV 感染中的作用，并讨论了这些与 GC 相关的病原体的一些分子机制。还讨论了研究差距和未来展望。
