Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Department of Digital Health, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of Korea.
Sci Rep. 2023 Nov 30;13(1):21101. doi: 10.1038/s41598-023-48474-x.
Malnutrition might play a key role in the prognosis of patients with Crohn's disease (CD). The aim of this study was to explore the impact of weight loss from diagnosis of CD to one-year post-diagnosis on disease prognosis in terms of surgery. Patients who were diagnosed with CD at Samsung Medical Center between 1995 to 2020 were included in this study. The study defined the "group with weight loss" as patients with weight loss in one year after diagnosis and the "group without body weight loss" as patients without weight loss in one year after diagnosis. Their data such as demographics, laboratory findings, and medical interventions were collected retrospectively. The primary outcome was confirmation of the difference in the incidence of surgery associated with CD between the group with weight loss and the group without body weight loss. We further analyzed factors associated with surgery outcomes. A total of 165 patients were analyzed in this study. Forty-one patients (24.8%) had body weight loss whereas 124 patients (75.2%) had no body weight loss. Body change at one year showed no significant association with direct surgical incidence. However, the patients with weight loss tended to undergo surgery earlier than patients without body weight loss. Among factors associated with outcomes of Crohn's surgery, the albumin was the only significant factor. Patients with weight loss had no statistically significant increase in the risk of surgery than patients without weight loss, although they tended to undergo surgery earlier than patients without body weight loss. A prospective study is needed to determine serial body weight changes during follow-up for patients with CD.
营养不良可能在克罗恩病（CD）患者的预后中发挥关键作用。本研究旨在探讨从 CD 诊断到诊断后一年体重减轻对手术预后的影响。本研究纳入了 1995 年至 2020 年期间在三星医疗中心诊断为 CD 的患者。研究将“体重减轻组”定义为诊断后一年内体重减轻的患者，将“无体重减轻组”定义为诊断后一年内无体重减轻的患者。回顾性收集他们的人口统计学、实验室发现和医疗干预等数据。主要结局是确认体重减轻组与无体重减轻组之间与 CD 相关的手术发生率的差异。我们进一步分析了与手术结果相关的因素。本研究共分析了 165 例患者。41 例（24.8%）患者体重减轻，124 例（75.2%）患者无体重减轻。一年时的体重变化与直接手术发生率无显著相关性。然而，与无体重减轻的患者相比，体重减轻的患者更倾向于更早接受手术。在与克罗恩病手术结果相关的因素中，白蛋白是唯一具有显著意义的因素。尽管体重减轻的患者比无体重减轻的患者更早接受手术，但手术风险没有统计学意义增加。需要进行前瞻性研究，以确定 CD 患者随访期间体重的连续变化。
