2型糖尿病成人血糖控制与总医疗费用关系的经济评估:回顾性队列研究

An Economic Evaluation of the Relationship Between Glycemic Control and Total Healthcare Costs for Adults with Type 2 Diabetes: Retrospective Cohort Study.

作者信息

Boye Kristina S, Bae Jay P, Thieu Vivian T, Lage Maureen J

机构信息

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46225, USA.

HealthMetrics Outcomes Research, 28 Riverside Lane, Madison, CT, 06443, USA.

出版信息

Diabetes Ther. 2024 Feb;15(2):395-407. doi: 10.1007/s13300-023-01507-0. Epub 2023 Dec 1.

Abstract

INTRODUCTION

Glycemic control is associated with better outcomes among individuals with type 2 diabetes (T2D). This research examines total US all-cause medical costs for adults with T2D with recommended glycemic control (HbA1c < 7%) compared to poor glycemic control (HbA1c ≥ 7%).

METHODS

The study used administrative claims data linked to HbA1c laboratory test results from January 1, 2015 through June 30, 2021 to identify adults with T2D with a recorded HbA1c test. Patients with recommended glycemic control at index date were propensity score matched to patients with poor glycemic control. General linear models and two-part models were used to compare all-cause outpatient, drug, acute care and total costs for 1 year post index date.

RESULTS

The study included 59,830 propensity-matched individuals. Results indicate that recommended glycemic control, compared to poor glycemic control, was associated with statistically significantly lower all-cause acute care ($23,868 ± $21,776 vs. $24,352 ± $22,223), drug ($10,277 ± $14,671 vs. $10,540 ± $14,928), and total medical costs ($41,381 ± $42,757 vs. $42,054 ± $43,422) but significantly higher outpatient costs ($7290 ± $12,028 vs. $7026 ± $11,587) (all p < 0.0001). Sensitivity analyses examined results based upon alternative HbA1c thresholds of ≤ 6.5% and < 8%. Results were generally robust to alternative HbA1c thresholds, with higher HbA1c thresholds associated with higher all-cause total costs as well as increased savings for having HbA1c below threshold.

CONCLUSIONS

Glycemic control was associated with significantly lower all-cause total, drug, and acute care medical costs. Given the high prevalence of T2D in the USA, our results suggest potential economic benefits associated with glycemic control for healthcare providers.

摘要

引言

血糖控制与2型糖尿病(T2D)患者更好的预后相关。本研究调查了美国T2D成人患者中,血糖控制良好(糖化血红蛋白[HbA1c]<7%)与血糖控制不佳(HbA1c≥7%)者的全因医疗费用。

方法

本研究使用了2015年1月1日至2021年6月30日期间与HbA1c实验室检测结果相关的行政索赔数据,以识别有HbA1c检测记录的T2D成人患者。将索引日期时血糖控制良好的患者与血糖控制不佳的患者进行倾向评分匹配。使用一般线性模型和两部分模型比较索引日期后1年的全因门诊、药物、急性护理和总费用。

结果

该研究纳入了59830名倾向匹配个体。结果表明,与血糖控制不佳相比,血糖控制良好与全因急性护理费用(23868±21776美元 vs. 24352±22223美元)、药物费用(10277±14671美元 vs. 10540±14928美元)和总医疗费用(41381±42757美元 vs. 42054±43422美元)在统计学上显著降低相关,但门诊费用显著更高(7290±12028美元 vs. 7026±11587美元)(所有p<0.0001)。敏感性分析根据≤6.5%和<8%的替代HbA1c阈值检查结果。结果对替代HbA1c阈值通常具有稳健性,较高的HbA1c阈值与较高的全因总费用以及HbA1c低于阈值时增加的节省相关。

结论

血糖控制与显著更低的全因总、药物和急性护理医疗费用相关。鉴于T2D在美国的高患病率,我们的结果表明血糖控制对医疗保健提供者具有潜在的经济效益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd5c/10838884/93accb39a7f2/13300_2023_1507_Fig1_HTML.jpg

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