International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
J Hum Hypertens. 2024 Mar;38(3):277-285. doi: 10.1038/s41371-023-00877-z. Epub 2023 Dec 1.
Hypertension (HTN) is a common chronic condition associated with increased morbidity and mortality. Anthropometric indices of adiposity are known to be associated with a risk of HTN. The aim of this study was to identify the anthropometric indices that best associate with HTN in an Iranian population. 9704 individuals aged 35-65 years were recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study. Demographic and anthropometric data of all participants were recorded. HTN was defined as a systolic blood pressure (SBP) ≥ 140 mmHg, and/ or a diastolic blood pressure (DBP) ≥ 90 mmHg on two subsequent measurements, or being treated with oral drug therapy for BP. Data mining methods including Logistic Regression (LR), Decision Tree (DT), and Bootstrap Forest (BF) were applied. Of 9704 participants, 3070 had HTN, and 6634 were normotensive. LR showed that body roundness index (BRI), body mass index (BMI) and visceral adiposity index (VAI) were significantly associated with HTN in both genders (P < 0.0001). BRI showed the greatest association with HTN (OR = 1.276, 95%CI = (1.224, 1.330)). For BMI we had OR = 1.063, 95%CI = (1.047, 1.080), for VAI we had OR = 1.029, 95%CI = (1.020, 1.038). An age < 47 years and BRI < 4.04 was associated with a 90% probability of being normotensive. The BF indicated that age, sex and BRI had the most important role in HTN. In summary, among anthropometric indices the most powerful indicator for discriminating hypertensive from normotensive patients was BRI.
高血压（HTN）是一种常见的慢性疾病，与发病率和死亡率的增加有关。肥胖的人体测量学指标与 HTN 的风险相关。本研究的目的是确定在伊朗人群中与 HTN 关联最好的人体测量学指标。9704 名年龄在 35-65 岁的人作为马什哈德中风和心脏动脉粥样硬化疾病（MASHAD）研究的一部分被招募。所有参与者的人口统计学和人体测量学数据均被记录。HTN 的定义为两次连续测量收缩压（SBP）≥140mmHg，或舒张压（DBP）≥90mmHg，或正在服用口服降压药物治疗。应用了数据挖掘方法，包括逻辑回归（LR）、决策树（DT）和自举森林（BF）。在 9704 名参与者中，有 3070 人患有 HTN，6634 人血压正常。LR 显示，在男女两性中，体圆指数（BRI）、体重指数（BMI）和内脏脂肪指数（VAI）均与 HTN 显著相关（P<0.0001）。BRI 与 HTN 的相关性最强（OR=1.276，95%CI=（1.224，1.330））。对于 BMI，我们有 OR=1.063，95%CI=（1.047，1.080），对于 VAI，我们有 OR=1.029，95%CI=（1.020，1.038）。年龄<47 岁和 BRI<4.04 与血压正常的概率为 90%相关。BF 表明，年龄、性别和 BRI 在 HTN 中起最重要的作用。总之，在人体测量学指标中，区分高血压和血压正常患者的最强指标是 BRI。
