范科尼贫血的两个互补组对DNA交联处理的表型反应有所不同。
Two complementation groups of Fanconi's anemia differ in their phenotypic response to a DNA-crosslinking treatment.
作者信息
Moustacchi E, Papadopoulo D, Diatloff-Zito C, Buchwald M
出版信息
Hum Genet. 1987 Jan;75(1):45-7. doi: 10.1007/BF00273837.
PMID:3804331
Abstract
The two genetic complementation groups reported for Fanconi's anemia (FA) correspond to two phenotypic classes as characterized by measurements of the rate of DNA semiconservative synthesis after 8-methoxypsoralen photoaddition. This test allows a rapid genetic classification of FA patients which appears to be a prerequisite for investigations of the biochemical defect(s) in FA.
摘要
范可尼贫血（FA）报道的两个基因互补组对应于两个表型类别，这是通过测量8-甲氧基补骨脂素光加成后DNA半保留合成速率来表征的。该测试可对FA患者进行快速基因分类，这似乎是研究FA生化缺陷的先决条件。
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