Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Science, Beijing, China.
Appl Environ Microbiol. 2023 Dec 21;89(12):e0166223. doi: 10.1128/aem.01662-23. Epub 2023 Dec 4.
Antibiotics can induce dose-dependent hormetic effects on bacterial cell proliferation, i.e., low-dose stimulation and high-dose inhibition. However, the underlying molecular basis has yet to be clarified. Here, we showed that sulfonamides play dual roles as a weapon and signal against that can modulate cell physiology and phenotype. Subsequently, through investigating the hormesis mechanism, we proposed a comprehensive regulatory pathway for the hormetic effects of low-level sulfonamides and determined the generality of the observed regulatory model in the Comamonadaceae family. Considering the prevalence of Comamonadaceae in human guts and environmental ecosystems, we provide critical insights into the health and ecological effects of antibiotics.
抗生素可以诱导细菌细胞增殖的剂量依赖性的激效作用，即低剂量刺激和高剂量抑制。然而，其潜在的分子基础尚未阐明。在这里，我们表明磺胺类药物具有双重作用，既是对抗 的武器又是信号分子，可调节细胞生理和表型。随后，通过研究激效作用机制，我们提出了一个针对低水平磺胺类药物的激效作用的综合调控途径，并确定了在丛毛单胞菌科家族中观察到的调控模型的普遍性。考虑到丛毛单胞菌在人类肠道和环境生态系统中的普遍存在，我们为抗生素对健康和生态的影响提供了重要的见解。
