Tianjin University of Chinese Medicine, Tianjin, China.
Clinical Pharmacology Department, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Phytother Res. 2024 Jan;38(1):411-453. doi: 10.1002/ptr.8033. Epub 2023 Dec 5.
Ischemic stroke (IS) remains one of the leading causes of death and disability in humans. Unfortunately, none of the treatments effectively provide functional benefits to patients with IS, although many do so by targeting different aspects of the ischemic cascade response. The advantages of traditional Chinese medicine (TCM) in preventing and treating IS are obvious in terms of early treatment and global coordination. The efficacy of TCM and its bioactive constituents has been scientifically proven over the past decades. Based on clinical trials, this article provides a review of commonly used TCM patent medicines and herbal decoctions indicated for IS. In addition, this paper also reviews the mechanisms of bioactive constituents in TCM for the treatment of IS in recent years, both domestically and internationally. A comprehensive review of preclinical and clinical studies will hopefully provide new ideas to address the threat of IS.
缺血性脑卒中（IS）仍然是人类死亡和残疾的主要原因之一。不幸的是，尽管许多治疗方法通过靶向缺血级联反应的不同方面来实现，但没有一种治疗方法能有效地为 IS 患者提供功能益处。中医药（TCM）在预防和治疗 IS 方面具有明显的优势，体现在早期治疗和整体协调方面。过去几十年的科学研究已经证明了 TCM 的疗效及其生物活性成分的功效。基于临床试验，本文对常用于 IS 的 TCM 专利药物和草药方剂进行了综述。此外，本文还回顾了近年来国内外 TCM 生物活性成分治疗 IS 的作用机制。对临床前和临床研究的全面综述有望为应对 IS 的威胁提供新的思路。
