Department of Gynecology, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zibo 255036, Shandong, China.
Acta Biochim Pol. 2023 Dec 5;70(4):955-961. doi: 10.18388/abp.2020_6902.
The cell adhesion protein cadherin 19 (CDH19) has been reported to be involved in various types of cancer, but its role in cervical carcinoma remains unknown. We collected and analyzed the patients' data using the GEPIA Kaplan-Meier plotter databases. CDH19 was overexpressed in cervical carcinoma cells to assess its effect on cell proliferation and activation of AKT and NF-κB signaling pathways. A xenograft mouse model was established to study the function of CDH19 in vivo. We found that CDH19 expression was significantly downregulated in cervical carcinoma tissues compared to adjacent normal tissues. Patients with high expression of CDH19 had a significantly better overall survival rate than those with low CDH19 expression. CDH19 expression was negatively correlated with the expression of the proliferation marker Ki-67, and overexpression of CDH19 significantly inhibited cervical carcinoma cell proliferation. Furthermore, overexpression of CDH19 suppressed the activation of the AKT and NF-κB signaling pathways, and CDH19-overexpressing cervical carcinoma tumors exhibited significantly slower growth in vivo. CDH19 plays an important role in cervical carcinoma by suppressing both cell proliferation and the activation of AKT and NF-κB signaling pathways. Therefore, CDH19 may be a potential therapeutic target for cervical carcinoma.
细胞黏附蛋白 cadherin 19（CDH19）已被报道参与多种类型的癌症，但它在宫颈癌中的作用尚不清楚。我们使用 GEPIA Kaplan-Meier plotter 数据库收集和分析了患者的数据。在宫颈癌细胞中过表达 CDH19，以评估其对细胞增殖和 AKT 和 NF-κB 信号通路激活的影响。建立异种移植小鼠模型以研究 CDH19 在体内的功能。我们发现，与相邻正常组织相比，宫颈癌组织中 CDH19 的表达明显下调。CDH19 高表达的患者总生存率明显高于 CDH19 低表达的患者。CDH19 的表达与增殖标志物 Ki-67 的表达呈负相关，过表达 CDH19 可显著抑制宫颈癌细胞的增殖。此外，过表达 CDH19 抑制了 AKT 和 NF-κB 信号通路的激活，CDH19 过表达的宫颈癌肿瘤在体内的生长明显减慢。CDH19 通过抑制细胞增殖和 AKT 和 NF-κB 信号通路的激活在宫颈癌中发挥重要作用。因此，CDH19 可能是宫颈癌的潜在治疗靶点。
