性别和自体外周血造血干细胞移植后时间对多发性骨髓瘤患者免疫重建的影响是什么？
Gender and the length of time since autologous hematopoietic stem cell transplantation-What is their influence on the immune reconstitution in multiple myeloma patients?
机构信息
Team of Food and Nutrition, Department of Dietetics, Faculty of Health Sciences, Poznan University of Physical Education, Poznań, Poland.
Department of Haematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznań, Poland.
出版信息
PLoS One. 2023 Dec 7;18(12):e0295308. doi: 10.1371/journal.pone.0295308. eCollection 2023.
INTRODUCTION
In the literature there is lack of information on the influence of gender and time since autologous hematopoietic stem cell transplantation (HSCT) on the immune reconstitution in multiple myeloma (MM) patients.
OBJECTIVE
The aim of this study was to assess the diversity of the immune reconstitution according to gender in MM patients after autologous HSCT on the day of the clinic discharge and on the 29th day after discharge, as well as to investigate the changes in the immune system in females and males after staying at home for 28 days.
METHOD
The studied population comprised 13 females and 13 males after autologous HSCT. On the day of the clinic discharge and on the 29th day after discharge blood samples were taken to analyse 22 immunological parameters. Statistical analysis was performed using STATISTICA 10 StatSoft Poland. For multiple comparisons, the Bonferroni correction was used.
RESULTS
No statistically significant differences were observed in the analysed immunological parameters between the studied females and males with MM on the day of the clinic discharge and on the 29th day after discharge. However, on the 29th day after the clinic discharge compared to the day of the clinic discharge, statistically significant differences were found in 8 immunological parameters among females and 6 immunological parameters among males.
CONCLUSION AND RECOMMENDATION
Our results indicate that the immune reconstitution is similar but not the same in patients of both genders. Statistically significant differences in the immune response in the studied females and males imply that gender may play a role in the immune reconstitution and that the results obtained in MM patients should be analysed separately in females and males. In order to explain the observed changes in the immune system according to gender, further research should be carried out on a larger population. This would most probably make it possible to find their clinical application.
简介
文献中缺乏关于性别和自体外周血造血干细胞移植（HSCT）后时间对多发性骨髓瘤（MM）患者免疫重建影响的信息。
目的
本研究旨在评估女性和男性多发性骨髓瘤患者自体外周血造血干细胞移植后第 29 天和出院当天的免疫重建情况，评估性别对免疫重建的影响，以及女性和男性在出院后 28 天在家中时免疫系统的变化。
方法
研究对象为 13 例女性和 13 例男性多发性骨髓瘤患者自体外周血造血干细胞移植后。在出院当天和第 29 天采集血样，分析 22 项免疫学参数。采用 STATISTICA 10 StatSoft Poland 进行统计学分析。对于多重比较，使用 Bonferroni 校正。
结果
出院当天和第 29 天，研究的女性和男性多发性骨髓瘤患者的分析免疫参数之间无统计学差异。然而，与出院当天相比，出院第 29 天，女性的 8 项免疫参数和男性的 6 项免疫参数有统计学差异。
结论和建议
我们的结果表明，两性患者的免疫重建相似但不完全相同。研究中女性和男性免疫反应的统计学差异表明，性别可能在免疫重建中起作用，应分别分析女性和男性 MM 患者的结果。为了解释根据性别观察到的免疫系统变化，应在更大的人群中进行进一步的研究。这很可能使找到它们的临床应用成为可能。
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