Virginia Tech Carilion School of Medicine, Roanoke, VA.
Division of Cardiovascular Disease, Department of Medicine, Carilion Clinic, Roanoke, VA.
Cardiovasc Pathol. 2019 May-Jun;40:41-46. doi: 10.1016/j.carpath.2019.02.002. Epub 2019 Feb 10.
A rare case of extramedullary multiple myeloma causing cardiac tamponade secondary to a plasma cell-based pericardial effusion is described. A systematic search using PubMed (National Library of Medicine) was used to identify a further 27 cases dating back to 1970. Case characteristics, treatment strategies, and survival time following tamponade are discussed. Linear regression demonstrated a weak but statistically significant correlation between survival time following tamponade and treatment with systemic chemotherapy and steroids (β=16.8 weeks, P=.009). However, this manifestation of extramedullary multiple myeloma still conveys a dismal prognosis with a median survival following tamponade of only 6 weeks based on our review.
描述了一例罕见的骨髓外多发性骨髓瘤导致的心包填塞，其继发于浆细胞性心包积液。使用 PubMed（美国国立医学图书馆）进行系统检索，确定了自 1970 年以来的另外 27 例病例。讨论了病例特征、治疗策略以及心包填塞后的生存时间。线性回归显示，心包填塞后生存时间与全身化疗和类固醇治疗之间存在微弱但具有统计学意义的相关性（β=16.8 周，P=.009）。然而，根据我们的回顾，这种骨髓外多发性骨髓瘤的表现仍然预示着预后不良，心包填塞后的中位生存时间仅为 6 周。
