Tang Lei, Chen Xin, Hou Jianquan, Wei Xuedong
Department of Urology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, 215006, People's Republic of China.
Department of Urology, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou, 215006, People's Republic of China.
J Transl Med. 2025 Jan 4;23(1):9. doi: 10.1186/s12967-024-06022-9.
CXCL14 is a highly conserved chemokine expressed in various cell types, playing crucial roles in both physiological and pathological processes, including immune regulation and tumorigenesis. Recently, the role of CXCL14 in tumors has attracted considerable attention. However, previous pan-cancer studies have reported inconsistencies regarding the effects of CXCL14 on tumors, particularly concerning its expression levels in tumor tissues and its influence on various phenotypes of cancer cells. This variability is believed to stem from the context-dependent nature of CXCL14, as different sources of CXCL14 and its secretion within distinct tumor microenvironments may mediate diverse biological effects. Such phenomena have also been observed in prostate cancer research. Despite a foundational understanding of CXCL14 in prostate cancer, there remains a lack of comprehensive reviews summarizing the specific roles of this chemokine and systematically analyzing the reasons behind its complex effects. Therefore, this article aims to discuss the role of CXCL14 in the tumor microenvironment of prostate cancer and explore future research directions and potential applications.
CXCL14是一种在多种细胞类型中表达的高度保守的趋化因子，在包括免疫调节和肿瘤发生在内的生理和病理过程中发挥着关键作用。最近，CXCL14在肿瘤中的作用引起了相当大的关注。然而，先前的泛癌研究报告了CXCL14对肿瘤影响的不一致性，特别是关于其在肿瘤组织中的表达水平及其对癌细胞各种表型的影响。这种变异性被认为源于CXCL14的背景依赖性，因为不同来源的CXCL14及其在不同肿瘤微环境中的分泌可能介导不同的生物学效应。这种现象在前列腺癌研究中也有观察到。尽管对前列腺癌中的CXCL14有了基本的了解，但仍然缺乏全面的综述来总结这种趋化因子的具体作用，并系统地分析其复杂效应背后的原因。因此，本文旨在探讨CXCL14在前列腺癌肿瘤微环境中的作用，并探索未来的研究方向和潜在应用。
