阿尔茨海默病患者的身体活动水平与生活方式、预期寿命及生活质量之间的关联
The Association between Levels of Physical Activity and Lifestyle, Life Expectancy, and Quality of Life in Patients with Alzheimer's Disease.
作者信息
Gholamalishahi Shima, Hosseini Seyed Ali, Ettorre Evaristo, Mannocci Alice, Okechukwu Chidiebere Emmanuel, Keshavarz Mohamad Javad, La Torre Giuseppe
机构信息
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00161 Rome, Italy.
Department of Sport Physiology, Islamic Azad University, Shiraz 7198774731, Iran.
出版信息
J Clin Med. 2023 Nov 26;12(23):7327. doi: 10.3390/jcm12237327.
BACKGROUND
Engaging in physical activity could help improve the quality of life in patients with Alzheimer's disease. The objective of this study was to determine the association between the levels of physical activity and lifestyle, life expectancy, and quality of life in patients with Alzheimer's disease in Iran and Italy.
METHODS
A total of 165 participants from Iran and Italy were enrolled in this cross-sectional study. In Iran, 85 patients participated in the study. In Italy, we enrolled 80 patients at the Sapienza University teaching hospital, Policlinico Umberto 1 in Rome. The inclusion criteria in this study include patients over 60 years old, non-smokers, and non-users of antidepressants and hypnotics.
RESULTS
The results of Tukey's post hoc test of the study conducted in Iran showed that the lifestyle of patients with moderate ( = 0.001) and low ( = 0.009) physical activity levels was significantly better than inactive patients. Life expectancy in patients with moderate physical activity levels was significantly higher than inactive patients ( = 0.011). The quality of life was significantly better in patients with moderate ( = 0.001) and low ( = 0.002) physical activity levels than inactive patients. On the other hand, the findings of Tukey's post hoc test of the study in Italy showed that the quality of life in patients with low ( = 0.001) and moderate physical activity levels ( = 0.01) was significantly higher than inactive patients.
CONCLUSIONS
A low to moderate level of physical activity could be associated with an improved lifestyle, life expectancy, and quality of life in patients with Alzheimer's disease compared to inactivity.
背景
进行体育活动有助于改善阿尔茨海默病患者的生活质量。本研究的目的是确定伊朗和意大利阿尔茨海默病患者的体育活动水平与生活方式、预期寿命和生活质量之间的关联。
方法
共有来自伊朗和意大利的165名参与者纳入了这项横断面研究。在伊朗，85名患者参与了研究。在意大利，我们在罗马的萨皮恩扎大学教学医院翁贝托一世综合医院招募了80名患者。本研究的纳入标准包括60岁以上的患者、非吸烟者以及未使用抗抑郁药和催眠药的患者。
结果
在伊朗进行的该研究的Tukey事后检验结果显示，中等（P = 0.001）和低（P = 0.009）体育活动水平患者的生活方式明显优于不活动的患者。中等体育活动水平患者的预期寿命明显高于不活动的患者（P = 0.011）。中等（P = 0.001）和低（P = 0.002）体育活动水平患者的生活质量明显优于不活动的患者。另一方面，在意大利进行的该研究的Tukey事后检验结果显示，低（P = 0.001）和中等体育活动水平（P = 0.01）患者的生活质量明显高于不活动的患者。
结论
与不活动相比，低至中等水平的体育活动可能与阿尔茨海默病患者改善的生活方式、预期寿命和生活质量相关。
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