心肺适能与美国退伍军人中阿尔茨海默病及相关痴呆症的风险。
Cardiorespiratory fitness and risk of Alzheimer's disease and related dementias among American veterans.
机构信息
Washington DC VA Medical Center, Washington, DC, USA.
George Washington University, Washington, DC, USA.
出版信息
Alzheimers Dement. 2023 Oct;19(10):4325-4334. doi: 10.1002/alz.12998. Epub 2023 Mar 22.
INTRODUCTION
Cardiorespiratory fitness (CRF) is associated with improved health and survival. Less is known about its association with Alzheimer's disease and related dementias (ADRD).
METHODS
We identified 649,605 US veterans 30 to 95 years of age and free of ADRD who completed a standardized exercise tolerance test between 2000 and 2017 with no evidence of ischemia. We examined the association between five age- and sex-specific CRF categories and ADRD incidence using multivariate Cox regression models.
RESULTS
During up to 20 (median 8.3) years of follow-up, incident ADRD occurred in 44,105 (6.8%) participants, with an incidence rate of 7.7/1000 person-years. Compared to the least-fit, multivariable-adjusted hazard ratios (95% confidence intervals) for incident ADRD were: 0.87 (0.85-0.90), 0.80 (0.78-0.83), 0.74 (0.72-0.76), and 0.67 (0.65-0.70), for low-fit, moderate-fit, fit, and high-fit individuals, respectively.
DISSCUSSION
These findings demonstrate an independent, inverse, and graded association between CRF and incident ADRD. Future studies may determine the amount and duration of physical activity needed to optimize ADRD risk reduction.
简介
心肺适能（CRF）与健康状况的改善和生存时间的延长有关。其与阿尔茨海默病和相关痴呆症（ADRD）的关系则知之甚少。
方法
我们确定了 649605 名年龄在 30 至 95 岁之间的美国退伍军人，他们在 2000 年至 2017 年间完成了一项标准化的运动耐量测试，且没有缺血的证据。我们使用多变量 Cox 回归模型检查了五个年龄和性别特异性的 CRF 类别与 ADRD 发病率之间的关联。
结果
在长达 20 年（中位数 8.3 年）的随访期间，44105 名（6.8%）参与者发生了 ADRD，发病率为 7.7/1000 人年。与最不适合的人相比，多变量调整后的发病风险比（95%置信区间）为：0.87（0.85-0.90）、0.80（0.78-0.83）、0.74（0.72-0.76）和 0.67（0.65-0.70），分别对应低、中、高 fit 和高 fit 的个体。
讨论
这些发现表明 CRF 与 ADRD 发病率之间存在独立、反向和分级的关联。未来的研究可能会确定需要多少和多长时间的身体活动才能优化 ADRD 风险降低。
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