The CORE Institute, Phoenix, Arizona.
OrthoCarolina Hip and Knee Center and Atrium Musculoskeletal Institute, Charlotte, North Carolina.
J Arthroplasty. 2024 Jun;39(6):1455-1458. doi: 10.1016/j.arth.2023.12.002. Epub 2023 Dec 8.
Glucagon-Like Peptide agonists have traditionally been used for glycemic control in diabetic patients. However, there has been a dramatic rise in their utilization for weight loss management. As such, arthroplasty surgeons will encounter an increasing number of patients on these medications, and therefore it is important to understand the implications of their use in the perioperative period. This review will describe the pharmacological actions of these medications as well as the impact on hip and knee arthroplasty patients, and considerations for perioperative management. Because of the rapid adaption and utilization of these drugs, the science is evolving at a fast pace. More and longer-term studies are needed to truly understand the impact of these medications on total joint arthroplasty utilization and in management of these patients in the perioperative period.
胰高血糖素样肽激动剂传统上被用于糖尿病患者的血糖控制。然而，它们在减肥管理中的应用急剧增加。因此，关节置换外科医生将遇到越来越多使用这些药物的患者，因此了解它们在围手术期的使用意义重大。这篇综述将描述这些药物的药理作用以及对髋关节和膝关节置换患者的影响，并讨论围手术期管理的注意事项。由于这些药物的快速适应和应用，科学正在迅速发展。需要更多和更长时间的研究来真正了解这些药物对全关节置换术应用的影响，以及在围手术期管理这些患者的影响。
