抑郁症与肌肉减少症相关特征：一项孟德尔随机化研究。
Depression and sarcopenia-related traits: A Mendelian randomization study.
作者信息
Wang Ding-Kun, Li Yi-Hao, Guo Xiao-Ming
机构信息
Department of Neurosurgery, Tongde Hospital of Zhejiang Province, Hangzhou 310016, Zhejiang Province, China.
Department of Neurosurgery, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310012, Zhejiang Province, China.
出版信息
World J Psychiatry. 2023 Nov 19;13(11):929-936. doi: 10.5498/wjp.v13.i11.929.
BACKGROUND
Observational studies have suggested that depression is associated with sarcopenia. However, the causal relationship between depression and sarcopenia remains unclear.
AIM
To investigate the causal relationship between depression and sarcopenia.
METHODS
We performed a Mendelian randomization (MR) analysis to identify the bidirectional relationship between depression and sarcopenia-related traits. Summary-level data and independent variants used as instrumental variables came from large genome-wide association studies of depression (414055 cases and 892299 controls), of appendicular lean mass (ALM, 450243 participants), and of hand grip strength (exposure: 360000 participants; outcome: 334925 participants).
RESULTS
We identified a negative association of depression with lower ALM [odds ratio (OR): 0.932, 95% confidence interval (95%CI): 0.889-0.979, = 0.005]. In the reverse MR analysis, we also observed an inverse association of hand grip strength with depression (OR: 0.200, 95%CI: 0.108-0.370, < 0.001). Similar results were obtained in sensitivity analyses.
CONCLUSION
Depression was causally related to decreased muscle mass, and declined muscle strength might lead to a higher risk of depression.
背景
观察性研究表明抑郁症与肌肉减少症有关。然而，抑郁症与肌肉减少症之间的因果关系仍不清楚。
目的
研究抑郁症与肌肉减少症之间的因果关系。
方法
我们进行了孟德尔随机化（MR）分析，以确定抑郁症与肌肉减少症相关特征之间的双向关系。用作工具变量的汇总数据和独立变体来自抑郁症（414055例病例和892299例对照）、四肢瘦体重（ALM，450243名参与者）和握力（暴露组：360000名参与者；结局组：334925名参与者）的大型全基因组关联研究。
结果
我们发现抑郁症与较低的ALM呈负相关[优势比（OR）：0.932，95%置信区间（95%CI）：0.889 - 0.979， = 0.005]。在反向MR分析中，我们还观察到握力与抑郁症呈负相关（OR：0.200，95%CI：0.108 - 0.370， < 0.001）。敏感性分析也得到了类似结果。
结论
抑郁症与肌肉量减少存在因果关系，而肌肉力量下降可能导致患抑郁症的风险更高。
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