Department of Supportive and Palliative Care, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-Ku, Osaka, 541-8567, Japan.
Department of Medical Innovation, Osaka University Hospital, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Support Care Cancer. 2024 Jun 19;32(7):445. doi: 10.1007/s00520-024-08645-6.
Advanced cancer patients have nutrition impact symptoms (NISs), while many of them have depressive moods. This study aimed to determine the associations of NISs with depression.
This study was a secondary analysis. The dietary intake and 19 NISs in patients receiving palliative care were evaluated using 10-point scales, and the patients were categorized into two groups (non-depression and depression groups) using the cutoff based on the Patient Health Questionnaire-9 (PHQ-9). To determine associations between depression and the number of NISs with a score of ≥ 4, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the logistic regression model were calculated.
A total of 225 participants were divided into the non-depression group (n = 148) and the depression group (n = 77). The prevalence of depression was 34.2%. Dietary intake was lower, and the number of NISs with a score of ≥ 4 was higher in the depression group (both p < 0.001). All NISs were more severe in the depression group. Significant differences were observed in 15 of the 19 NISs. In the logistic regression model, significantly higher adjusted ORs were observed in the groups with 4-6 NISs and 7 or more NISs with a score of ≥ 4 (10.76 [95% CI, 2.07-55.91], p = 0.016; 17.02 [95% CI, 3.08-94.22], p < 0.001) than in the group with no NISs with a score of ≥ 4.
Having four or more NISs with a score ≥ 4 was associated with depression.
晚期癌症患者存在营养影响症状（NISs），其中许多患者存在抑郁情绪。本研究旨在确定 NISs 与抑郁之间的关系。
本研究为二次分析。采用 10 分制评估接受姑息治疗患者的饮食摄入和 19 项 NISs，并根据患者健康问卷-9（PHQ-9）的截断值将患者分为两组（非抑郁组和抑郁组）。为了确定抑郁与 NISs 数量之间的关系，计算了具有≥4 分的 NISs 的比值比（OR）和 95%置信区间（CI）的校正优势比（OR）。
共纳入 225 名参与者，分为非抑郁组（n=148）和抑郁组（n=77）。抑郁的患病率为 34.2%。抑郁组的饮食摄入较低，NISs 评分≥4 的数量较高（均 P<0.001）。抑郁组的所有 NISs 均更为严重。在 19 项 NISs 中有 15 项存在显著差异。在逻辑回归模型中，NISs 评分≥4 的 4-6 项和 7 项及以上的组的校正后 OR 显著更高（10.76[95%CI，2.07-55.91]，P=0.016；17.02[95%CI，3.08-94.22]，P<0.001），而 NISs 评分≥4 的无项组则无显著差异。
有 4 项或更多 NISs 评分≥4 与抑郁相关。
