患有罕见遗传性凝血障碍的女性的妊娠、分娩及新生儿结局
Pregnancy, childbirth and neonatal outcomes of women with rare inherited coagulation disorders.
作者信息
McCann Lucy Jane, Scullion Erin, Doy Lauren, Ciantar Etienne
机构信息
The Faculty of Medicine and Health, University of Leeds, Leeds, UK.
The Faculty of Epidemiology and Population Health, The London School of Hygiene and Tropical Medicine, London, UK.
出版信息
Obstet Med. 2023 Dec;16(4):222-227. doi: 10.1177/1753495X221148813. Epub 2023 Jan 18.
BACKGROUND
We aimed to describe the characteristics and the pregnancy outcomes of women with rare inherited coagulation factor disorders managed at a tertiary obstetric-haematology unit in the United Kingdom.
METHODS
A retrospective service evaluation was conducted using routinely collected medical records. Descriptive analyses were applied to investigate pregnancy, childbirth and neonatal management and outcomes.
RESULTS
Overall, 20 patients with rare inherited coagulation disorders were included who birthed 30 live infants from 29 pregnancies. Regarding maternal bleeding outcomes, 3% experienced antepartum haemorrhage, 38% of pregnancies experienced primary post-partum haemorrhage, and none experienced secondary post-partum haemorrhage. Five (17%) neonates had cranial ultrasound scans for imaging to investigate for a neonatal haemorrhage, which were all normal.
CONCLUSIONS
Although women with rare inherited coagulation disorders may be more susceptible to complications in pregnancy, within this cohort there was no evidence that the condition led to increased morbidity or mortality when best practices were observed.
背景
我们旨在描述在英国一家三级产科血液科接受治疗的患有罕见遗传性凝血因子疾病的女性的特征及妊娠结局。
方法
使用常规收集的病历进行回顾性服务评估。采用描述性分析来调查妊娠、分娩及新生儿管理情况和结局。
结果
总体而言，纳入了20例患有罕见遗传性凝血障碍的患者，她们在29次妊娠中共分娩30例活产婴儿。关于孕产妇出血结局，3%的患者发生产前出血，38%的妊娠发生原发性产后出血，无一例发生继发性产后出血。5例（17%）新生儿接受了头颅超声扫描以检查是否有新生儿出血，结果均正常。
结论
尽管患有罕见遗传性凝血障碍的女性在妊娠期间可能更容易出现并发症，但在该队列中，没有证据表明在遵循最佳实践的情况下，这种疾病会导致发病率或死亡率增加。
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