Gudziol H, Katenkamp D, Küttner K, Beleites E
Laryngol Rhinol Otol (Stuttg). 1986 Dec;65(12):666-70.
The leading symptom in all patients was a nasal obstruction. At first all three cases of olfactory neuroblastoma were mistaken for polyposis nasi. The tumour can be diagnosed solely by histologic examination. The light microscopic as well as the ultrastructural findings demonstrated the great morphological variability of this carcinoma. In nearly all cases a definite diagnosis is possible if besides the light microscopic picture also clinical data, ultrastructural and, if necessary, immunohistochemical findings are considered. At the time of diagnosis one tumour was Kadish-stage A and two were stage C. Lokal and metastatic tumour extension, recurrence of disease after treatment, patient age and radical tumour resection at initial presentation, are prognostic important criteria. The discriminant function by Homzie and Elkon permits the oncologist to predict the patient's outcome accurately.
所有患者的主要症状均为鼻塞。起初，3例嗅神经母细胞瘤均被误诊为鼻息肉。该肿瘤仅通过组织学检查即可确诊。光镜及超微结构检查结果显示，这种癌具有很大的形态学变异性。几乎在所有病例中，若除光镜图像外，还考虑临床资料、超微结构以及必要时的免疫组化结果，就有可能做出明确诊断。诊断时，1例肿瘤为卡迪什A期，2例为C期。局部及转移瘤扩展、治疗后疾病复发、患者年龄以及初次就诊时肿瘤的根治性切除，都是重要的预后标准。霍姆齐和埃尔孔提出的判别函数可使肿瘤学家准确预测患者的预后。
