围手术期红细胞输血对上皮性卵巢癌患者预后的影响。
Impact of perioperative red blood cell transfusion on the prognosis of patients with epithelial ovarian cancer.
作者信息
Zheng Yawen, Zhang Wenxia, Chen Yafei, Yang Xingsheng, Dong Ruiying
机构信息
Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
出版信息
Heliyon. 2023 Nov 30;9(12):e23081. doi: 10.1016/j.heliyon.2023.e23081. eCollection 2023 Dec.
BACKGROUND
Surgery for advanced ovarian cancer tends to be extensive. We performed an analysis to determine whether perioperative red blood cell transfusion (PRBCT) is associated with a poor prognosis in women with epithelial ovarian cancer (EOC).
METHODS
Our retrospective analysis included 314 women. The Mann-Whitney rank-sum test and chi-square test were used to analyze the clinical characteristics of the PRBCT and non-PRBCT groups, and Cox proportional hazard models were used for the multivariate analysis.
RESULTS
PRBCT was associated with higher relapse and mortality rates in 121 (38.54 %) patients. After multivariate analysis, transfused patients were 1.59 times at risk of death (hazard ratio [HR] = 1.59; 95%CI, 1.12-2.25) and 1.63 times at risk of recurrence (HR = 1.63; 95%CI, 1.22-2.18) than non-transfused patients.
CONCLUSIONS
PRBCT could prolong hospital stay, and increased hospital costs were significantly associated with increased cancer recurrence and overall mortality in patients with EOC.
背景
晚期卵巢癌手术往往范围广泛。我们进行了一项分析，以确定围手术期红细胞输血（PRBCT）是否与上皮性卵巢癌（EOC）女性患者的不良预后相关。
方法
我们的回顾性分析纳入了314名女性。采用曼-惠特尼秩和检验和卡方检验分析PRBCT组和非PRBCT组的临床特征，并使用Cox比例风险模型进行多变量分析。
结果
121名（38.54%）患者的PRBCT与较高的复发率和死亡率相关。多变量分析后，输血患者的死亡风险是未输血患者的1.59倍（风险比[HR]=1.59；95%CI，1.12-2.25），复发风险是未输血患者的1.63倍（HR=1.63；95%CI，1.22-2.18）。
结论
PRBCT可能会延长住院时间，增加住院费用，且与EOC患者癌症复发和总死亡率增加显著相关。
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