Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
Bull Exp Biol Med. 2023 Nov;176(1):77-81. doi: 10.1007/s10517-023-05974-0. Epub 2023 Dec 12.
We showed for the first time that polymorphisms rs2075938 and rs2075938 of the NCF4 gene are associated with the risk of chronic heart failure in patients with type 2 diabetes mellitus (n=1310). In particular, haplotypes ATGTCTAT (OR=1.74, 95%CI=1.23-2.47; p=0.0017) and ATATTCAC (OR=2.83, 95%CI=1.33-6.03; p=0.0072) of NCF4 increase the risk of chronic heart failure in type 2 diabetes mellitus patients. The results show that NADPH oxidase subunit NCF4 is involved in the molecular mechanisms of myocardial damage in type 2 diabetes mellitus.
我们首次表明，NCF4 基因的 rs2075938 和 rs2075938 多态性与 2 型糖尿病患者慢性心力衰竭的风险相关（n=1310）。特别是，NCF4 的 ATGTCTAT（OR=1.74，95%CI=1.23-2.47；p=0.0017）和 ATATTCAC（OR=2.83，95%CI=1.33-6.03；p=0.0072）单体型增加了 2 型糖尿病患者慢性心力衰竭的风险。结果表明，NADPH 氧化酶亚单位 NCF4 参与了 2 型糖尿病心肌损伤的分子机制。
