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一位未确诊肢端肥大症患者的主动脉瓣窦瘤样扩张。

Aneurysmal dilation of sinus of Valsalva in a patient with undiagnosed acromegaly.

作者信息

Gharoy Hoda, Taghavi Sepideh, Ghaemmaghami Zahra, Rabiei Parham, Afzalnia Azadeh

机构信息

Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences Tehran Iran.

Heart Valve Disease Research Center, Rajaie Cardiovascular Medical and Research Center Iran University of Medical Sciences Tehran Iran.

出版信息

Clin Case Rep. 2023 Dec 11;11(12):e8326. doi: 10.1002/ccr3.8326. eCollection 2023 Dec.

DOI:10.1002/ccr3.8326
PMID:38089482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10714056/
Abstract

KEY CLINICAL MESSAGE

In patients presenting with aortic ectasia and myxomatous valve diseases at young ages, possible underlying acromegaly should be in mind.

ABSTRACT

Acromegaly is a chronic systemic disease mainly caused by the benign pituitary adenoma secreting growth hormone (GH) in excess. Acromegaly is associated with various complications such as cardiovascular diseases. In this regard, timely diagnosis, and management of these patients could be life-saving. Herein, a case of aneurysmal dilation of the sinus of Valsalva with severe aortic and mitral regurgitation in a patient with undiagnosed acromegaly is presented.

摘要

关键临床信息

对于年轻时出现主动脉扩张和黏液瘤样瓣膜疾病的患者，应考虑潜在的肢端肥大症。

摘要

肢端肥大症是一种慢性全身性疾病，主要由分泌过量生长激素（GH）的垂体良性腺瘤引起。肢端肥大症与各种并发症相关，如心血管疾病。在这方面，及时诊断和治疗这些患者可能会挽救生命。本文介绍了一例未确诊肢端肥大症患者出现主动脉瓣窦瘤样扩张并伴有严重主动脉瓣和二尖瓣反流的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4977/10714056/1b1f6d7a340c/CCR3-11-e8326-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4977/10714056/07820d80d4ab/CCR3-11-e8326-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4977/10714056/bcb9fce36bdb/CCR3-11-e8326-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4977/10714056/6ba80ff0a513/CCR3-11-e8326-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4977/10714056/a70cac95b60a/CCR3-11-e8326-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4977/10714056/1b1f6d7a340c/CCR3-11-e8326-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4977/10714056/07820d80d4ab/CCR3-11-e8326-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4977/10714056/bcb9fce36bdb/CCR3-11-e8326-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4977/10714056/6ba80ff0a513/CCR3-11-e8326-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4977/10714056/a70cac95b60a/CCR3-11-e8326-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4977/10714056/1b1f6d7a340c/CCR3-11-e8326-g004.jpg

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本文引用的文献

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Preoperative Medical Treatment for Patients With Acromegaly: Yes or No?肢端肥大症患者的术前药物治疗：是或否？
J Endocr Soc. 2022 Aug 4;6(9):bvac114. doi: 10.1210/jendso/bvac114. eCollection 2022 Sep 1.
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Advances in Research on the Cardiovascular Complications of Acromegaly.肢端肥大症心血管并发症的研究进展
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Multidisciplinary management of acromegaly: A consensus.肢端肥大症的多学科管理：共识。
Rev Endocr Metab Disord. 2020 Dec;21(4):667-678. doi: 10.1007/s11154-020-09588-z. Epub 2020 Sep 10.
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Pituitary tumors: epidemiology and clinical presentation spectrum.垂体瘤：流行病学和临床表现谱。
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Natural History of Acromegaly: Incidences, Re-operations, Cancers, and Mortality Rates in a National Cohort.肢端肥大症的自然史：国家队列中的发病率、再次手术率、癌症和死亡率。
Neuroendocrinology. 2020;110(11-12):977-987. doi: 10.1159/000505332. Epub 2019 Dec 11.
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CARDIOVASCULAR COMPLICATIONS OF ACROMEGALY.肢端肥大症的心血管并发症
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Bringing Cardiovascular Comorbidities in Acromegaly to an Update. How Should We Diagnose and Manage Them?肢端肥大症中心血管合并症的最新进展。我们应如何诊断和管理这些合并症？
Front Endocrinol (Lausanne). 2019 Mar 7;10:120. doi: 10.3389/fendo.2019.00120. eCollection 2019.
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Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update.肢端肥大症的全身并发症及当前治疗现状的影响：最新进展。
Endocr Rev. 2019 Feb 1;40(1):268-332. doi: 10.1210/er.2018-00115.
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Cardiovascular Disease in Acromegaly.肢端肥大症中的心血管疾病
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Complications of acromegaly: cardiovascular, respiratory and metabolic comorbidities.肢端肥大症的并发症：心血管、呼吸及代谢共病
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