Levy M, Guesry P, Loirat C, Dommergues J P, Nivet H, Habib R
Contrib Nephrol. 1979;16:132-40. doi: 10.1159/000402887.
14 children with proven or presumably immunologically mediated tubulo-interstitial nephritis are presented. In 2 patients anti-tubular basement membrane antibodies were detected. In 6 immunofluorescence microscopy showed granular deposits of immunoglobulin and/or complement likely representing interstitial location of immune complexes. The findings by immunofluorescence were not significant in the remaining 6 patients. However, the association of renal disease to extra-renal disorders, namely chronic active hepatitis and ulcerative colitis, or uveitis or the presence of an epithelioid granuloma with multinucleated giant cells suggests that in such patients an immunologic disorder might be responsible for the tubulo-interstitial nephritis.
本文报告了14例经证实或推测为免疫介导的肾小管间质性肾炎患儿。2例患者检测到抗肾小管基底膜抗体。6例免疫荧光显微镜检查显示免疫球蛋白和/或补体颗粒状沉积，可能代表免疫复合物的间质定位。其余6例患者免疫荧光检查结果不显著。然而，肾脏疾病与肾外疾病（即慢性活动性肝炎和溃疡性结肠炎）、葡萄膜炎或存在上皮样肉芽肿及多核巨细胞之间的关联表明，在此类患者中，免疫紊乱可能是肾小管间质性肾炎的病因。
