Department of Neurology, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, 100191, China.
PF Center of Excellence, Department of Neurology, UC Davis Medical Center, UC Davis School of Medicine, Sacramento, California, USA.
Ann Clin Transl Neurol. 2024 Mar;11(3):554-563. doi: 10.1002/acn3.51975. Epub 2023 Dec 14.
This study aimed to explore the association between slow-wave sleep and the progression of motor and nonmotor symptoms in patients with PD.
Data were collected from the Parkinson's Progression Markers Initiative study. Slow-wave sleep, also known as deep non-rapid eye movement (DNREM) sleep, was objectively assessed using the Verily Study Watch. Motor function was assessed using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale Part III score, Hoehn and Yahr stage, freezing of gait, motor fluctuations, and dyskinesia severity. Comprehensive assessments were conducted on nonmotor symptoms, including depression, anxiety, global cognitive function, and autonomic dysfunction. Statistical analyses involved repeated-measures analysis of variance and linear regression.
A total of 102 patients with PD were included in the study, with a median follow-up duration of 3.4 years. In the long DNREM sleep duration group (n = 55), better motor function (DNREM × time interaction: F = 4.866, p = 0.030), less severe sexual dysfunction (p = 0.026), and improved activities of daily living (p = 0.033) were observed at the last follow-up visit compared with the short DNREM sleep duration group (n = 47). Reduced DNREM sleep duration is a risk factor for motor progression (β = -0.251, p = 0.021; 95% confidence interval = -0.465 to -0.038).
The findings suggest an association between longer DNREM sleep duration and slower motor and nonmotor progression in patients with PD.
本研究旨在探讨慢波睡眠与帕金森病（PD）患者运动和非运动症状进展之间的关系。
数据来自帕金森病进展标志物倡议研究。使用 Verily 研究手表客观评估慢波睡眠，也称为深度非快速眼动（DNREM）睡眠。运动功能采用运动障碍协会统一帕金森病评定量表第三部分评分、Hoehn 和 Yahr 分期、冻结步态、运动波动和运动障碍严重程度进行评估。对非运动症状进行综合评估，包括抑郁、焦虑、整体认知功能和自主神经功能障碍。统计分析采用重复测量方差分析和线性回归。
共纳入 102 例 PD 患者，中位随访时间为 3.4 年。在长 DNREM 睡眠时间组（n=55），最后一次随访时运动功能更好（DNREM×时间交互作用：F=4.866，p=0.030），性功能障碍更轻（p=0.026），日常生活活动能力改善（p=0.033），而在短 DNREM 睡眠时间组（n=47）则较差。DNREM 睡眠持续时间减少是运动进展的危险因素（β=-0.251，p=0.021；95%置信区间=-0.465 至-0.038）。
这些发现表明，PD 患者较长的 DNREM 睡眠时间与较慢的运动和非运动进展之间存在关联。
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