肢端肥大症伴巨大左心室肥厚：肥厚型梗阻性心肌病的拟表型还是表型？

Massive Left Ventricular Hypertrophy With Acromegaly: Hypertrophic Obstructive Cardiomyopathy Phenocopy or Phenotype?

作者信息

Tilkens Blair, Galazka Patrycja, Solis Joaquin, Crouch John D, Tajik A Jamil

机构信息

Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers, Milwaukee, Wisconsin, USA.

Department of Cardiothoracic Surgery, Aurora Sinai/Aurora St. Luke's Medical Centers, Milwaukee, Wisconsin, USA.

出版信息

JACC Case Rep. 2023 Sep 26;25:102033. doi: 10.1016/j.jaccas.2023.102033. eCollection 2023 Nov 1.

DOI:10.1016/j.jaccas.2023.102033

PMID:38094214

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10715936/

Abstract

Acromegaly-a rare endocrine disorder-results when a growth hormone-secreting somatotroph pituitary adenoma leads to increased insulin-like growth factor 1 production. Acromegaly is known to cause left ventricular hypertrophy. We present a case of acromegaly with massive left ventricular hypertrophy that was determined to be coexistent with gene-positive hypertrophic obstructive cardiomyopathy. ().

摘要

肢端肥大症是一种罕见的内分泌疾病，当分泌生长激素的垂体生长激素细胞腺瘤导致胰岛素样生长因子1分泌增加时就会引发该病。已知肢端肥大症会导致左心室肥厚。我们报告一例肢端肥大症合并巨大左心室肥厚的病例，经诊断该病例同时存在基因阳性肥厚型梗阻性心肌病。（）