一系列人膀胱癌异种移植瘤的生长及组织学特征

The growth and histological characteristics of a series of human bladder cancer xenografts.

作者信息

Hay J H, Busuttil A, Steel C M, Duncan W

出版信息

Radiother Oncol. 1986 Dec;7(4):331-40. doi: 10.1016/s0167-8140(86)80063-9.

Abstract

Xenografts from human transitional cell carcinoma of the bladder (TCC) have been successfully established in CBA mice which had previously been immune-deprived by thymectomy and whole body irradiation with cytosine arabinoside pre-treatment. Xenografts were established from 3/17 patients with histological grade 2 tumours, 3/19 patients with histological grade 3 tumours, and one from a patient with a mixed transitional cell and squamous cell carcinoma. No xenografts were established from patients with histological grade 1 tumours. All the xenografts maintained the histological characteristics of their parent tumours in early passage, but some developed more prominent squamous features in later generations. Many of the xenografts were cystic.

摘要

来自人膀胱移行细胞癌（TCC）的异种移植瘤已成功在CBA小鼠中建立，这些小鼠先前已通过胸腺切除术和全身照射并预先用阿糖胞苷进行免疫剥夺。从17例组织学2级肿瘤患者中的3例、19例组织学3级肿瘤患者中的3例以及1例患有移行细胞和鳞状细胞混合癌的患者中建立了异种移植瘤。没有从组织学1级肿瘤患者中建立异种移植瘤。所有异种移植瘤在早期传代时都保持了其亲本肿瘤的组织学特征，但有些在后代中出现了更明显的鳞状特征。许多异种移植瘤是囊性的。