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阿尔茨海默病的免疫疗法。

Immunotherapies for Alzheimer's disease.

机构信息

Department of Pharmacology and Chemical Biology, Department of Neurology, Center for Neurodegenerative Disease, Goizueta Institute Emory Brain Health, Emory University School of Medicine, Atlanta, GA, USA.

出版信息

Science. 2023 Dec 15;382(6676):1242-1244. doi: 10.1126/science.adj9255. Epub 2023 Dec 14.

DOI:10.1126/science.adj9255
PMID:38096276
Abstract

Antibodies targeting amyloid-β aggregates slow decline in Alzheimer's disease.

摘要

靶向淀粉样β聚集物的抗体可减缓阿尔茨海默病的衰退。

相似文献

[1]
Immunotherapies for Alzheimer's disease.

Science. 2023-12-15

[2]
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Rev Neurol (Paris). 2014-12

[3]
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[4]
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[5]
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[6]
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Expert Opin Biol Ther. 2013-9-22

[7]
Bapineuzumab: anti-β-amyloid monoclonal antibodies for the treatment of Alzheimer's disease.

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[8]
Structural aspects of Alzheimer's disease immunotherapy targeted against amyloid-beta peptide.

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[9]
Amyloid-Directed Antibodies: Past, Present, and Future.

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[10]
Is there still any hope for amyloid-based immunotherapy for Alzheimer's disease?

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引用本文的文献

[1]
Neuroinflammation and nutrition in Alzheimer's disease.

Front Neurol. 2025-7-23

[2]
Sodium benzoate treatment decreased amyloid beta peptides and improved cognitive function among patients with Alzheimer's disease: secondary analysis of a randomized clinical trial.

Transl Psychiatry. 2025-8-5

[3]
Cell-type-directed network-correcting combination therapy for Alzheimer's disease.

Cell. 2025-7-15

[4]
Structure-based discovery of forsythoside A as an effective inhibitor to reduce the neurotoxicity of amyloid β.

Commun Chem. 2025-7-4

[5]
Mimicking the structure and function of tau folds associated with disease.

Nat Chem. 2025-5-23

[6]
Sanshen San Formula Hinders Cognitive Function and Pathology in Alzheimer's Disease Through Potentiating the Function of Synapse.

CNS Neurosci Ther. 2025-4

[7]
Cerebral Amyloid Angiopathy: Clinical Presentation, Sequelae and Neuroimaging Features-An Update.

Biomedicines. 2025-3-1

[8]
The role of protein phosphorylation modifications mediated by iron metabolism regulatory networks in the pathogenesis of Alzheimer's disease.

Front Aging Neurosci. 2025-2-25

[9]
Posterior cingulate cortex microRNA dysregulation differentiates cognitive resilience, mild cognitive impairment, and Alzheimer's disease.

Alzheimers Dement. 2025-2

[10]
Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease.

bioRxiv. 2024-12-13

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