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Mimicking the structure and function of tau folds associated with disease.

作者信息

Schymkowitz Joost, Rousseau Frederic

机构信息

Switch Laboratory, VIB Center for Brain and Disease Research, Leuven, Belgium.

Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

出版信息

Nat Chem. 2025 May 23. doi: 10.1038/s41557-025-01841-9.

DOI:10.1038/s41557-025-01841-9

PMID:40410574

Abstract

摘要

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本文引用的文献

Macrocyclic β-arch peptides that mimic the structure and function of disease-associated tau folds.

Nat Chem. 2025 Apr 30. doi: 10.1038/s41557-025-01805-z.

GSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments.

Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2414176121. doi: 10.1073/pnas.2414176121. Epub 2024 Dec 18.

FDA approves second TTR stabilizer for cardiac amyloidosis.

Nat Rev Drug Discov. 2025 Jan;24(1):6. doi: 10.1038/d41573-024-00188-z.

Local structural preferences in shaping tau amyloid polymorphism.

Nat Commun. 2024 Feb 3;15(1):1028. doi: 10.1038/s41467-024-45429-2.

Immunotherapies for Alzheimer's disease.

Science. 2023 Dec 15;382(6676):1242-1244. doi: 10.1126/science.adj9255. Epub 2023 Dec 14.

Disease-specific tau filaments assemble via polymorphic intermediates.

Nature. 2024 Jan;625(7993):119-125. doi: 10.1038/s41586-023-06788-w. Epub 2023 Nov 29.

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.

Nature. 2023 Sep;621(7980):701-710. doi: 10.1038/s41586-023-06437-2. Epub 2023 Sep 27.

Mechanisms and pathology of protein misfolding and aggregation.

Nat Rev Mol Cell Biol. 2023 Dec;24(12):912-933. doi: 10.1038/s41580-023-00647-2. Epub 2023 Sep 8.

Cryo-EM structures of amyloid-β 42 filaments from human brains.

Science. 2022 Jan 14;375(6577):167-172. doi: 10.1126/science.abm7285. Epub 2022 Jan 13.

Structure-based classification of tauopathies.

Nature. 2021 Oct;598(7880):359-363. doi: 10.1038/s41586-021-03911-7. Epub 2021 Sep 29.

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相似文献

Mimicking the structure and function of tau folds associated with disease.

Nat Chem. 2025 May 23. doi: 10.1038/s41557-025-01841-9.

Macrocyclic β-arch peptides that mimic the structure and function of disease-associated tau folds.

Nat Chem. 2025 Apr 30. doi: 10.1038/s41557-025-01805-z.

The Lys 280 → Gln mutation mimicking disease-linked acetylation of Lys 280 in tau extends the structural core of fibrils and modulates their catalytic properties.

Protein Sci. 2021 Apr;30(4):785-803. doi: 10.1002/pro.4030. Epub 2021 Feb 9.

Distinct tau filament folds in human MAPT mutants P301L and P301T.

Nat Struct Mol Biol. 2025 May 29. doi: 10.1038/s41594-025-01575-9.

Novel tau filament folds in individuals with mutations P301L and P301T.

bioRxiv. 2024 Aug 17:2024.08.15.608062. doi: 10.1101/2024.08.15.608062.

Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy.

Elife. 2022 Mar 4;11:e76494. doi: 10.7554/eLife.76494.

Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile Dementia.

bioRxiv. 2023 Jan 23:2023.01.09.523314. doi: 10.1101/2023.01.09.523314.

Folding of the Tau Protein on Microtubules.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10347-51. doi: 10.1002/anie.201501714. Epub 2015 Jun 19.

Electrostatics of Tau Protein by Molecular Dynamics.

Biomolecules. 2019 Mar 23;9(3):116. doi: 10.3390/biom9030116.

Disease-associated patterns of acetylation stabilize tau fibril formation.

Structure. 2023 Sep 7;31(9):1025-1037.e4. doi: 10.1016/j.str.2023.05.020. Epub 2023 Jun 21.

本文引用的文献

Macrocyclic β-arch peptides that mimic the structure and function of disease-associated tau folds.

Nat Chem. 2025 Apr 30. doi: 10.1038/s41557-025-01805-z.

GSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments.

Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2414176121. doi: 10.1073/pnas.2414176121. Epub 2024 Dec 18.

FDA approves second TTR stabilizer for cardiac amyloidosis.

Nat Rev Drug Discov. 2025 Jan;24(1):6. doi: 10.1038/d41573-024-00188-z.

Local structural preferences in shaping tau amyloid polymorphism.

Nat Commun. 2024 Feb 3;15(1):1028. doi: 10.1038/s41467-024-45429-2.

Immunotherapies for Alzheimer's disease.

Science. 2023 Dec 15;382(6676):1242-1244. doi: 10.1126/science.adj9255. Epub 2023 Dec 14.

Disease-specific tau filaments assemble via polymorphic intermediates.

Nature. 2024 Jan;625(7993):119-125. doi: 10.1038/s41586-023-06788-w. Epub 2023 Nov 29.

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.

Nature. 2023 Sep;621(7980):701-710. doi: 10.1038/s41586-023-06437-2. Epub 2023 Sep 27.

Mechanisms and pathology of protein misfolding and aggregation.

Nat Rev Mol Cell Biol. 2023 Dec;24(12):912-933. doi: 10.1038/s41580-023-00647-2. Epub 2023 Sep 8.

Cryo-EM structures of amyloid-β 42 filaments from human brains.

Science. 2022 Jan 14;375(6577):167-172. doi: 10.1126/science.abm7285. Epub 2022 Jan 13.

Structure-based classification of tauopathies.

Nature. 2021 Oct;598(7880):359-363. doi: 10.1038/s41586-021-03911-7. Epub 2021 Sep 29.

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Mimicking the structure and function of tau folds associated with disease.

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