University of Utah Health, Salt Lake City, and Intermountain Healthcare, Murray, Utah.
Obstet Gynecol. 2024 Jan 1;143(1):139-142. doi: 10.1097/AOG.0000000000005387. Epub 2023 Sep 28.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with increased risk for macro- and micro-thrombi. Consensus guidelines recommend use of thromboprophylaxis in nonobstetric patients with SARS-CoV-2 infection admitted to the hospital. National-level studies evaluating venous thromboembolism (VTE) among pregnant and postpartum individuals with and without SARS-CoV-2 infection have not been completed. We performed a retrospective cohort study of individuals aged 18 years or older delivering at more than 20 weeks of gestation with data in the MarketScan Commercial Insurance Database from 2016 through 2020. Of 811,008 deliveries, SARS-CoV-2 infection during pregnancy or through 6 weeks postpartum was associated with increased risk for VTE compared with no infection (1.0% vs 0.5%, adjusted hazard ratio 2.62, 95% CI 1.60-4.29). Findings support further consideration of thromboprophylaxis in the obstetric population with SARS-CoV-2 infection.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染与大、小血栓形成的风险增加有关。共识指南建议对因 SARS-CoV-2 感染而住院的非产科患者使用血栓预防。尚未完成对患有和不患有 SARS-CoV-2 感染的孕妇和产后个体的静脉血栓栓塞症（VTE）进行的国家级研究。我们对 2016 年至 2020 年 MarketScan 商业保险数据库中年龄在 18 岁及以上分娩超过 20 周的个体进行了回顾性队列研究。在 811,008 例分娩中，与无感染相比，妊娠期间或产后 6 周内感染 SARS-CoV-2 与 VTE 的风险增加相关（1.0% vs 0.5%，调整后的危险比 2.62，95%CI 1.60-4.29）。这些发现支持在 SARS-CoV-2 感染的产科人群中进一步考虑使用血栓预防。
