Garreau G, Sechter D
Encephale. 1978;4(5 Suppl):569-76.
A survey of 131 psychotic subjects treated with carpipramine and a synthesis of the Japanese, German and French publications about this drug were done. The most valuable results were obtained in hebephrenics and in depressed schizophrenics. Carpipramine has a definite desinhibitory action against motor retardation, lack of energy, ideo-motor slowliness and blunting of the affect. At low doses, paranoid schizophrenics become worse. The emerged delusional and anxious phenomena, can be avoided by using higher doses. This drug possesses two kinds of effects: antidelusional and desinhibitory actions. If it does not seem to be a true antidepressant, Carpipramine proves useful in deficits of the psychomotor tone, which were resistant to antidepressant drugs.
对131名接受卡比咪嗪治疗的精神病患者进行了一项调查,并对有关该药物的日本、德国和法国出版物进行了综合分析。在青春型精神分裂症患者和抑郁型精神分裂症患者中获得了最有价值的结果。卡比咪嗪对运动迟缓、精力缺乏、观念运动迟缓及情感迟钝具有明确的去抑制作用。低剂量时,偏执型精神分裂症患者病情会恶化。通过使用更高剂量可以避免出现的妄想和焦虑现象。这种药物具有两种作用:抗妄想作用和去抑制作用。如果卡比咪嗪似乎不是一种真正的抗抑郁药,那么它在对抗抑郁药有抵抗性的精神运动张力不足方面被证明是有用的。