Furr Todd, Grodman Brandon, Heffernan Jeremy
School of Medicine, American University of the Caribbean School of Medicine, Cupecoy, Sint Maarten, Netherlands Antilles.
Ascension Providence Hospital Network, Southfield, MI, USA.
Arch Clin Cases. 2023 Dec 14;10(4):175-178. doi: 10.22551/2023.41.1004.10269. eCollection 2023.
Esthesioneuroblastoma is a tumor arising from olfactory neuroepithelium with an incidence of four per million. This case presents a rare nasal cavity neoplasm with hemorrhagic properties that may lead to significant sequelae. We present a 69-year-old male patient who presented with worsening altered mental status over the past 6-7 months. His Glasgow coma scale was a nine, showing a large mass centered at the cribriform plate with extension intracranially, sinonasal cavity, and bilateral orbits on diagnostics. Bifrontal craniotomy was performed one day after admission with resection of the tumor in the cranial fossa and intranasally, and decompression of the brainstem, frontal lobes, and third ventricle. After surgery, the patient was managed in the intensive care unit but continued to deteriorate. He was confirmed to have no meaningful brain activity and eventually deceased seven days after admission. Depending on the tumor stage, esthesioneuroblastoma can have a favorable prognosis with proper therapies. Different surgical techniques for ENB lead to the question of which therapeutic modality is the best because of the tumor's gross hemorrhagic properties. With adjunctive radiation therapy and/or chemotherapy, more research can bring light to proper surgical techniques.
嗅神经母细胞瘤是一种起源于嗅神经上皮的肿瘤,发病率为百万分之四。该病例呈现出一种罕见的鼻腔肿瘤,具有出血特性,可能导致严重的后遗症。我们报告一名69岁男性患者,在过去6至7个月中出现精神状态恶化。他的格拉斯哥昏迷评分为9分,诊断显示在筛板处有一个巨大肿块,向颅内、鼻窦腔和双侧眼眶延伸。入院一天后进行了双额开颅手术,切除颅窝和鼻腔内的肿瘤,并对脑干、额叶和第三脑室进行减压。术后,患者在重症监护病房接受治疗,但病情持续恶化。确认他没有有意义的脑活动,最终在入院七天后死亡。根据肿瘤分期,嗅神经母细胞瘤通过适当的治疗可获得良好的预后。由于肿瘤具有严重的出血特性,嗅神经母细胞瘤的不同手术技术引发了哪种治疗方式最佳的问题。通过辅助放疗和/或化疗,更多的研究可以为适当的手术技术带来启示。