Department of Chemical Sciences, University of Johannesburg, Doornfontein Campus, Johannesburg, P.O Box 17011, 2028, South Africa.
Drug Discovery and Smart Molecules Research Laboratory, Department of Chemical Sciences, University of Johannesburg, Doornfontein, 2028, South Africa.
Chem Biodivers. 2024 Jan;21(1):e202301402. doi: 10.1002/cbdv.202301402. Epub 2023 Dec 15.
Drimia delagoensis has been utilized for its medicinal properties since antiquity. The bulb and leaves are predominantly composed of secondary metabolites that exhibit biological activity. The quantification of total phenolic and flavonoid content, as well as the assessment of antioxidant activity was conducted using the Folin-Ciocalteus method, coulometric analysis, DPPH and the FRAP assays. The ethyl acetate, aqueous, and hexane extracts of the bulb exhibited significantly high total phenolic contents (167.9000±0.3376 μg GAE/mg, 56.2500±0.0043 μg GAE/mg, and 26.4000±0.0198 μg GAE/mg, respectively) compared to the ethyl acetate (49.4400±0.1341 μg QE/mg), aqueous (9.5200±0.1274 μg QE/mg), and hexane leaf extracts (1.8091±0.0049 μg QE/mg). On the other hand, the ethyl acetate leaf extract exhibited the highest antioxidant and free radical scavenging activity. The ethyl acetate extract of D. delagoensis, was identified as a significant source of natural antioxidants, and its use in the management of diabetic foot ulcers linked with oxidative stress is supported.
德拉戈因斯百合从古至今一直因其药用价值而被利用。球茎和叶片主要由具有生物活性的次生代谢产物组成。采用 Folin-Ciocalteus 法、库仑分析、DPPH 和 FRAP 测定法,对总酚和类黄酮含量以及抗氧化活性进行了定量评估。球茎的乙酸乙酯、水和正己烷提取物的总酚含量(分别为 167.9000±0.3376 μg GAE/mg、56.2500±0.0043 μg GAE/mg 和 26.4000±0.0198 μg GAE/mg)明显高于乙酸乙酯(49.4400±0.1341 μg QE/mg)、水(9.5200±0.1274 μg QE/mg)和正己烷叶片提取物(1.8091±0.0049 μg QE/mg)。另一方面,乙酸乙酯叶片提取物表现出最高的抗氧化和自由基清除活性。德拉戈因斯百合的乙酸乙酯提取物被鉴定为天然抗氧化剂的重要来源,支持其在管理与氧化应激相关的糖尿病足溃疡中的应用。