Department of Translational Biomedicine and Neuroscience, University of Bari Medical School, Bari, Italy.
Tissue Cell. 2024 Feb;86:102288. doi: 10.1016/j.tice.2023.102288. Epub 2023 Dec 10.
Tertiary lymphoid structures (TLSs) are accumulations of lymphoid cells within non-lymphoid organs that share the cellular compartments, spatial organization, vasculature, chemokines, and function with secondary lymphoid organs, especially lymph nodes. TLSs are organized into a separate T cell and B cell compartments which contain germinal centers with follicular dendritic cells. In most cases, TLSs contain Peripheral Node addressin (PNAD) expressing high endothelial venules (HEVs). TLSs have been described in various mouse models of inflammation and are associated with a wide range of autoimmune diseases. Other than these, TLSs have been described in chronic allograft rejection and cancer.
三级淋巴结构 (TLSs) 是指在非淋巴器官内聚集的淋巴样细胞，它们具有与次级淋巴器官（尤其是淋巴结）相同的细胞区室、空间组织、脉管系统、趋化因子和功能。TLSs 被组织成一个独立的 T 细胞和 B 细胞区室，其中包含含有滤泡树突状细胞的生发中心。在大多数情况下，TLSs 含有表达外周淋巴结地址素 (PNAD) 的高内皮静脉 (HEV)。在各种炎症的小鼠模型中都描述了 TLSs，并与广泛的自身免疫性疾病有关。除此之外，TLSs 还在慢性移植物排斥反应和癌症中被描述。
