Division of Cancer Biology, The Institute of Cancer Research, London, UK.
Division of Cancer Biology, The Institute of Cancer Research, London, UK.
DNA Repair (Amst). 2024 Jan;133:103609. doi: 10.1016/j.dnarep.2023.103609. Epub 2023 Nov 28.
The mammalian SWI/SNF chromatin remodelling complexes are commonly dysregulated in cancer. These complexes contribute to maintaining genome stability through a variety of pathways. Recent research has highlighted an important interplay between genome instability and immune signalling, and evidence suggests that this interplay can modulate the response to immunotherapy. Here, we review emerging studies where direct evidence of this relationship has been uncovered in SWI/SNF deficient cells. We also highlight genome maintenance activities of SWI/SNF that could potentially shape immune responses and discuss potential therapeutic implications.
哺乳动物的 SWI/SNF 染色质重塑复合物在癌症中通常失调。这些复合物通过多种途径有助于维持基因组稳定性。最近的研究强调了基因组不稳定性和免疫信号之间的重要相互作用，并表明这种相互作用可以调节对免疫疗法的反应。在这里，我们回顾了在 SWI/SNF 缺陷细胞中发现这种关系的直接证据的新兴研究。我们还强调了 SWI/SNF 的基因组维护活动，这些活动可能会影响免疫反应，并讨论了潜在的治疗意义。
