多发性硬化症和视神经脊髓炎谱系障碍人群中的合并症：来自一个服务不足、低收入国家赞比亚的发现。
Comorbidity in the multiple sclerosis and neuromyelitis optica spectrum disorders population: findings from an underserved, low income country, Zambia.
机构信息
Djavad Mowafaghian Centre for Brain Health and Faculty of Medicine (Neurology), University of British Columbia, Canada.
Department of Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
出版信息
Mult Scler Relat Disord. 2024 Jan;81:105365. doi: 10.1016/j.msard.2023.105365. Epub 2023 Dec 8.
BACKGROUND
Comorbidities are common in multiple sclerosis (MS); little is known in neuromyelitis optica spectrum disorders (NMOSD) or outside high-income regions.
OBJECTIVE
Compare comorbidities in MS/NMOSD patients, Zambia.
METHODS
Comorbidities were compared for MS/NMOSD patients from Zambia's University Teaching Hospital using logistic regression.
RESULTS
Thirty-three were included (MS/NMOSD:17/16); 22 (67 %) females, mean age=35.6-years. Fifteen (46 %) had any comorbidity [MS/NMOSD:11/4], 14 physical (MS/NMOSD:10/4) and 6 psychiatric comorbidity (MS/NMOSD:5/1). Odds of any/any physical comorbidity was higher in MS versus NMOSD (age-adjusted odds ratio[aOR]=6.9;95 %CI:1.4-34.7,p=0.020/aOR=5.6;95 %:1.1-28.0,p=0.037).
CONCLUSIONS
Physical comorbidity affected >2-in-5 MS/NMOSD patients and psychiatric disorders ∼1-in-5. Odds of any/any physical comorbidity were >five-fold higher in MS versus NMOSD.
背景
合并症在多发性硬化症（MS）中很常见；在视神经脊髓炎谱系疾病（NMOSD）或高收入地区以外，知之甚少。
目的
比较赞比亚 MS/NMOSD 患者的合并症。
方法
使用逻辑回归比较赞比亚大学教学医院的 MS/NMOSD 患者的合并症。
结果
共纳入 33 例（MS/NMOSD：17/16）；22 例（67%）为女性，平均年龄为 35.6 岁。15 例（46%）有任何合并症[MS/NMOSD：11/4]，14 例为躯体合并症（MS/NMOSD：10/4），6 例为精神合并症（MS/NMOSD：5/1）。MS 患者发生任何/任何躯体合并症的几率高于 NMOSD（年龄调整后的比值比[aOR]=6.9；95%CI：1.4-34.7，p=0.020/aOR=5.6；95%CI：1.1-28.0，p=0.037）。
结论
超过 2/5 的 MS/NMOSD 患者存在躯体合并症，约 1/5 的患者存在精神障碍。MS 患者发生任何/任何躯体合并症的几率比 NMOSD 患者高 5 倍以上。
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