Huang Yinghong, Yan Rui, Zhang Yu, Wang Xiaoqin, Sun Hao, Zhou Hongliang, Zou Haowen, Xia Yi, Yao Zhijian, Shi Jiabo, Lu Qing
Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China; Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Nanjing, China.
Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China; Department of Clinical Psychology, The Affiliated Hangzhou First People's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, China.
Clin Neurophysiol. 2024 Jan;157:120-129. doi: 10.1016/j.clinph.2023.11.016. Epub 2023 Dec 3.
We conducted this resting-state functional magnetic resonance imaging (rsfMRI) study to characterize changes in regional homogeneity (ReHo) or fractional amplitude of low-frequency fluctuations (fALFF) in young adult patients with major depressive disorder (MDD), with or without non-suicidal self-injury (NSSI).
We recruited 54 MDD patients with NSSI (MDD/NSSI), 68 MDD patients without NSSI, which is referred to as simple MDD (sMDD), and 66 matched healthy controls (HCs). A combination of fALFF and ReHo analyses was conducted. The effects of NSSI on the brain and their relationship to clinical variables were examined in this study.
MDD/NSSI patients have decreased fALFF in the right superior frontal gyrus (SFG) and the right inferior parietal lobe (IPL), decreased ReHo in the right SFG and the right middle temporal gyrus (MTG) and the left middle occipital gyrus (MOG). fALFF and ReHo values of the right SFG are positively correlated. The ReHo values of the right SFG and the number of recent self-injuries are positively correlated; the fALFF values of the right SFG are negatively correlated with NSSI severity.
There is a difference in brain activity between MDD/NSSI and sMDD, which may serve as an important physiological marker to determine the risk of self-injury and suicide.
Abnormal brain activity in patients with NSSI may provide new perspectives and significant implications on the severity of MDD patients and the prevention of self-injury and suicide.
我们开展了这项静息态功能磁共振成像（rsfMRI）研究，以表征伴有或不伴有非自杀性自伤（NSSI）的成年抑郁症（MDD）患者的局部一致性（ReHo）或低频振幅分数（fALFF）的变化。
我们招募了54名伴有NSSI的MDD患者（MDD/NSSI）、68名不伴有NSSI的MDD患者（称为单纯MDD，即sMDD）以及66名匹配的健康对照者（HC）。进行了fALFF和ReHo分析相结合的研究。本研究考察了NSSI对大脑的影响及其与临床变量的关系。
MDD/NSSI患者右侧额上回（SFG）和右侧顶下小叶（IPL）的fALFF降低，右侧SFG、右侧颞中回（MTG）和左侧枕中回（MOG）的ReHo降低。右侧SFG的fALFF和ReHo值呈正相关。右侧SFG的ReHo值与近期自伤次数呈正相关；右侧SFG的fALFF值与NSSI严重程度呈负相关。
MDD/NSSI和sMDD之间存在大脑活动差异，这可能是确定自伤和自杀风险的重要生理标志物。
NSSI患者的大脑活动异常可能为MDD患者的严重程度以及自伤和自杀的预防提供新的视角和重要启示。
