Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.
Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Cancer Gene Ther. 2024 Jan;31(1):9-17. doi: 10.1038/s41417-023-00682-3. Epub 2023 Dec 15.
Human papillomavirus (HPV) is a class of envelope-free double-stranded DNA virus. HPV infection has been strongly associated with the development of many malignancies, such as cervical, anal and oral cancers. The viral oncoproteins E6 and E7 perform central roles on HPV-induced carcinogenic processes. During tumor development, it usually goes along with the activation of abnormal signaling pathways. E6 and E7 induces changes in cell cycle, proliferation, invasion, metastasis and other biological behaviors by affecting downstream tumor-related signaling pathways, thus promoting malignant transformation of cells and ultimately leading to tumorigenesis and progression. Here, we summarized that E6 and E7 proteins promote HPV-associated tumorigenesis and development by regulating the activation of various tumor-related signaling pathways, for example, the Wnt/β-catenin, PI3K/Akt, and NF-kB signaling pathway. We also discussed the importance of HPV-encoded E6 and E7 and their regulated tumor-related signaling pathways for the diagnosis and effective treatment of HPV-associated tumors.
人乳头瘤病毒（HPV）是一类无包膜的双链 DNA 病毒。HPV 感染与多种恶性肿瘤的发生密切相关，如宫颈癌、肛门癌和口腔癌。病毒癌蛋白 E6 和 E7 在 HPV 诱导的致癌过程中发挥核心作用。在肿瘤发展过程中，通常伴随着异常信号通路的激活。E6 和 E7 通过影响下游肿瘤相关信号通路，诱导细胞周期、增殖、侵袭、转移等生物学行为的改变，从而促进细胞的恶性转化，最终导致肿瘤的发生和发展。在这里，我们总结了 E6 和 E7 蛋白通过调节各种肿瘤相关信号通路的激活，如 Wnt/β-catenin、PI3K/Akt 和 NF-κB 信号通路，促进 HPV 相关肿瘤的发生和发展。我们还讨论了 HPV 编码的 E6 和 E7 及其调节的肿瘤相关信号通路在 HPV 相关肿瘤的诊断和有效治疗中的重要性。
